ID A0A226N502_CALSU Unreviewed; 1459 AA.
AC A0A226N502;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=CD109 antigen {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASZ78_016939 {ECO:0000313|EMBL:OXB62644.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB62644.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB62644.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB62644.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB62644.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB62644.1}.
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DR EMBL; MCFN01000204; OXB62644.1; -; Genomic_DNA.
DR STRING; 9009.A0A226N502; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF162; CD109 ANTIGEN; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1459
FT /note="CD109 antigen"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013076190"
FT DOMAIN 465..589
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 668..759
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1287..1371
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1459 AA; 162580 MW; 69E61888A71B8CC2 CRC64;
MAQSRAAGRL LLLFLACGSA AAGPTFLVAA PWNIRPGASV TVGVALLPGS PAQVAVRGVL
LRDNQTVVSR ELVFERDSFG TLVLPVLPLE SASGIYELLV EGHADGQRVF SNRTRLIYVA
KSISVFIQTD KSTYKPGQDV MFRIVTVYPD LKPYKASLNI YIRDPRKKLI QQWLLEEGDL
GVVSKKFQLS KNPPLGDWSI DVEVNGQVHY QRFKVMEYVL PKFDVMITTP LYYSLREKDV
TGVVTAKYTY GKPVKGNVTV TCLSVSYWTN KRNITKTMEI NGSVNITCNK LMLQNLNGDQ
SWHHGDDDYT EPVEIIAVVT ESLTGISQNS STIVFPKQSD YFIEFVDYSR VIKPSLNFIA
TLKVTRSDSN QLTAEERQNL VTITAQQSDL FFHHSSLSHF ENEATEERNK TVHVLNYTVP
ENGIIDIEFP ILSNTKTLRV QAEFLNSKTD IGVYDVFSSP SETYLQVKTK SQEVKAGKPF
ELNIESNKPV LSKEQIITSG TMVAKTFNIT AENSWAPLAC ILVFYVDELG AVVNDALTIP
VQPALDNKIK ISWSKDKVKP SEKVTLKMST THPESVIGLA VVDKSTKLLG ESSDITEDSV
FHELNLYNTA QYFPLVRGSF GVFQDSNLCF VDDGMIPIED GFGDDLPVAR DGPLDFSTPY
VRTHFPETWL WIDTKTRTDA DTTMEVTVPD TITSWVASAF VLSENGGLGV TTLPAELEAF
QPFFIFLNLP YSVIRGEQFI LEVNIFNYLK EEAEVNVILD VNDAFEILLT SNEINATGNQ
QSIFVPSEDG KTVQFPIKPK QLGEIPIKVT AISSAASDAI MQKVLVKAEG LEQTYSQTLL
LDLTGSKQQA VSKTLDFTFP SDVVSGSERV QVTAVGDLLG PSINGLSSLI KMPYGCGEQN
MINFAPNVYI LQYLTKTRQL REDIQSKALS FMRKGYQREL LFQRDDGSFS AFGNEDPSGS
TWLSAFVLRC FFQARPFIDI DQDVLMDTAK WIVGHQKSNG EFQEPGKVLH SDLQGGTNNP
ITLTAYIMSS LLGFQDKEHA YVIKRATNFL EDKLREGISD NYTLALVTYA LSWAKSTKAK
EALSMLNERA EQQGEFRFWI TPASEISDSW QPRSIDIELA AYALLSHFHQ DRLEEGIPIM
KWLSQQRNHL GGFSSTQDTV VALQALSLFA ALTSAHKTEM DVTVSATSLE TPEIFSIDTQ
NRFLLQTKEI PPVQPMTVTV SAEGRGFAVF QLNVIYNTKH ADRRLRSVQK QKAFDLDVDV
KDDKDDMNHL TLNVCTRYLG SDTSPRSGMV LMEVGLLSGF SVSPDFIPLD NTVKKMEEEN
GKVSLYLDTL NATQFCVDIP TVRDFKVANI QDASVTVVDY YEPSSEVTTH SAIRVGDMLL
DVAVASDLVI QSRNIHSSMG DRLNGANTTF VNRMADHYIL ALPYHAEGIQ KQRKPRRAMG
VERSERIPDL VTLENVIQT
//
