ID A0A226N557_CALSU Unreviewed; 2299 AA.
AC A0A226N557;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASZ78_003064 {ECO:0000313|EMBL:OXB62704.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB62704.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB62704.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB62704.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB62704.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB62704.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MCFN01000201; OXB62704.1; -; Genomic_DNA.
DR STRING; 9009.A0A226N557; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd22831; Gal_Rha_Lectin_PKD1L2; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF134; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 2; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1287..1306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1494..1515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1535..1556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1772..1796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1808..1839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1998..2020
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2032..2054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2074..2091
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2123..2143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2163..2185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2221..2250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..231
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 239..330
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 626..964
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1331..1448
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1562..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1885..1898
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2299 AA; 256634 MW; 3C9FD55DCCCDFC91 CRC64;
MLLKGQFFSE DLQGLIQTTM PEGKGVDMWT VTGSDTSDNW TEKRNSDDVT TQAFEEGIKK
SGDVVSNTSA MLGTKLKMWL GIPVLISLAL CLAVEKAADE EGIPCSKHQL AFNRSCYEFV
RLQRSFTSAQ RWCERGGGHL VFIENEETQE FLQKHIAEDQ EWWIGLISDS LLNETTDGSM
IWLDTSNTSY SNWYKDQPSP FPSTCGYILK NAKYQWGVTE NCSQEFDFIC EFENGQSIAC
DNYNATVQCG SGEVIQIGES FYGRKTPHYC VSETPSHNDT EEDCSWISVK DEVAGQCHGL
QACQVAADGT FFGEPCPASG SYLSIQYHCK EGLQLVVTDT CLIFENITIT LNWLLSPYSG
NLSCIISTGD GHTVDPYYPL PLLSNVTHRY SSPGEFIVFV ECSTSEWHVT AQKRVTVQDK
MDEVSITGCY SHHGSGNSSH CRALYGELLW IQVELNGGRG VSYTVLADNV TLTESRAEEG
TAPHNLTLDS AAQELLGPGV HQLAIRVSSN STSSEISESI TVHLIEPVSG LWAVLASHTL
KVGENLEINV SVSHGAPAEM MFEVVGSNET YSLWEDCPQG EPRTYIVPMH SEGTFLVKVV
ARNAFSNASL DIGFITVLAN SSHTEGACWP EWNECVQHQI ILTSQQEVQI PPSCLPPPKS
AVTVRVTVQS HGNEEQQDEQ CLYVTAKQDL QLEIRCEANC KPVNASEEVV LSVSGLKDSR
DLYYNWYLDN TFQNKSTPLP PACSLTGFRQ NSLNLLQSNT STLIMNSSFL QTHGAAFQIK
VTALTQHGYG EETYLVSTVP PPQVPSCAVS PRQGSVLTTF TVSCSTPCSV DSCQSSRSTQ
LNYCFYLNSN SLLHCGPDPE LFPVYLPLGE EENNFILPVT ITVSNSFGDT VQTNASVKVI
QADPIDGNLT LQTIVSEKTN TILKDGNNSM SLFQLFKSVT SVLNHETQEE NFNLSLQTDT
RKEVEASNTL KDVSASLLSV NTEDSRDDQK LTDAASYLFN AVSNVLQASI QNRAMNTTGP
EAEQSLVSHQ LLNTVENLQS ALLFGKEPDD EPMVLTTHSA TIYINSDTSF DISGTVGGLS
LTGLDGSIIP VSNLKENIEI ILPRHSAPQE DRIQLNLGNF SIFQVNITSE NTSIVIQLEC
EQDIPLILYL GYGYRPNETN YDMKNHLFYK KTTGGETNTW VLSPEELIFG EGTYYFMVSQ
DIGVDSTVYD SLAIAVTCFA SRCVFWDEQQ GNWNSFGCQV GPKTNSRSTQ CLCNHLTFFG
SSFFVIPNAV DVSKTAQLFG TFVDNPVVVT TVGCIFLIYV LVVIWARRKD IQDDAKAKIT
VLEDNDPFAQ YRYLVTVFTG HRRGAATTSK VTLTLYGLEG ESEPHHLSDP DTPVFERGGV
DVFLLCTFFP LGELQSIRLW HDNSGDNPSW YVNRVLVHDL AWDQKWYFLC NSWLAVDIGE
CVLDKVFPVA TEQDMKQFSN LFFMKTSKGF QDGHIWYSVF SRSPRSSFTR AQRVSCCFSL
LLCTMLTSIM FWGVPKDPAE QKMDLGKIEF TWQEVMIGFE SSLLMFPINL LIVQIFRNTR
PRPAMQGGEK KPGKNGQVSP SLPPAPQVTP SISLTPEAVI KDVRRIANSL FKALKAPSLT
SVSDLRKSTN INTLLALVED IICQQNRAGQ EFYDGNRKKD DTVIVTLGPT DMQEKRRSPT
PVKGMCERLK YSDYSRCLYM QLQHVEMELE LLGPHKFQMP QSYTRAVQQV QHMKNLLQNQ
ICSSASISER WSLIPSSSGD GKKSSSSKGL PWWFVFIAWF LVAATSGVSG FFTMLYGLHY
GKENSIKWLI SMAISFFESL FITQPLKVLG FAAFFALVLK KVEHEDDENT AIDGPLSAPG
FITDGNSKLV GSARIRQVRV KGDSCPISPT LQRVIRECHA PYSLRTEDTS DYGEHWNTSV
FDTSSDLSSA WQYQSQSKLR GQPIWGKLAT YGGGGYVVHL GTDPQNASRV LQYLFNNVWL
DTFTRAVFVE FTVYNANVNL FCIICLMFET NALGAFFPSA ELQSVRLYPY TNTLHIFVVA
AEVIYFLFVV YYMIVQGKLM KTLKWRYFHS KWNLLEMAII LISWSALSVF VKRTILGKRD
ISYYQEHKED SVSFNETARA DAVLGYLIAF LVLLSTVKLW HLLRLNPKLN MITSTLRRAW
GDISGFITVT AIMFLAYSIA TNLIFGWKLC SYKTLSDSAE TMVSLQLGIF NYEEILDYNP
ILGSFLIGSC IIFMTFVVLN LFISVILVAF SEEQKQYQAS EEEQIVDLML MKLFGFFGIK
CKKEEKTGCN DQPKQPVSD
//
