ID A0A226N803_CALSU Unreviewed; 797 AA.
AC A0A226N803;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=ASZ78_008972 {ECO:0000313|EMBL:OXB63657.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB63657.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB63657.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB63657.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB63657.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB63657.1}.
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DR EMBL; MCFN01000151; OXB63657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226N803; -.
DR STRING; 9009.A0A226N803; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00064; FU; 2.
DR CDD; cd12094; TM_ErbB2; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR049328; TM_ErbB1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF21314; TM_ErbB1; 1.
DR SMART; SM00261; FU; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..797
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012036579"
FT TRANSMEM 557..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..160
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT DOMAIN 175..330
FT /note="Furin-like cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF00757"
FT DOMAIN 353..472
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT DOMAIN 497..537
FT /note="Growth factor receptor"
FT /evidence="ECO:0000259|Pfam:PF14843"
FT DOMAIN 557..592
FT /note="Epidermal growth factor receptor-like transmembrane-
FT juxtamembrane segment"
FT /evidence="ECO:0000259|Pfam:PF21314"
FT REGION 588..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..709
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 86723 MW; 4025BF0C6BC5059F CRC64;
MIAARPLCPA LLPLLLLAAL CPSAAAEVCT GTDMKLLQPS SPESHYETLR HLYQGCQVVQ
GNLELTYLPP GADTAFLQDI KEVQGYVLIA ENHVSAVGLR GLRIIRGTQL FQERYALAVL
GNVGLRQLGM RQLTEILKGG VHIEGNPQLC FQETILWADI FHRHNELSGE THVESTRSRT
CPDCRALCPE GHCWGESPQD CQTLTNSICH GCPRCKGTKP TDCCHEQCAA GCTGPKHSDC
LACLNFNRSG ICELHCPPLV IYNSDTFESV PNRDGRYTFG ASCVSQCPYN YLATEVGSCT
LVCPQNSQEV TVNNVQKCEK CSKPCPEVCY GLGVDFLKGV RAVNASNIRH FAGCTKIFGS
LAFLPETFAG DPSTNTAPLD PQLLSVFESL EELTGYLYIA AWPPSMEDLG VFQNLRIIRG
RVLHNGAYSL TLRELAVRAL GLRALQEISS GMVLIHHNPQ LCFLQKVPWD SIFRHPRQRL
FQTHNKPPEQ CESEGLVCFH LCAHGHCWGP GPTQCVSCER FLRGQECVAS CNLLDGCTIR
DEDGCPVDQK PSQVTSIIAG VVGALLVVVL LLITVVCVKR RRQQERKHTM RRLLQETEST
AETPVDTTEA EDSAAFPFPP QSLVEGPECP VPEALEVDVG AKGAVPSPPA TRYSEDPTAL
PGDESEGLDP EGFATPAPHT TMPEYVNQAG ERPSPPRHPC TPPSPPEKPK GHQGKNGLIK
DTKHPFLGPF SHAVENPEYL APPGLPVPAA FSQAFDNPYY WNQDPPKAGG PEGSPSSTPA
AENPEYLGLA EPEDVAV
//
