ID A0A226NA13_CALSU Unreviewed; 1379 AA.
AC A0A226NA13;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
DE Flags: Fragment;
GN ORFNames=ASZ78_010007 {ECO:0000313|EMBL:OXB64424.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB64424.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB64424.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB64424.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB64424.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB64424.1}.
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DR EMBL; MCFN01000122; OXB64424.1; -; Genomic_DNA.
DR STRING; 9009.A0A226NA13; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024585; mTOR_dom.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF11865; DUF3385; 1.
DR SMART; SM01346; DUF3385; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 864..1034
FT /note="Serine/threonine-protein kinase mTOR"
FT /evidence="ECO:0000259|SMART:SM01346"
FT NON_TER 1379
FT /evidence="ECO:0000313|EMBL:OXB64424.1"
SQ SEQUENCE 1379 AA; 155150 MW; 9EC9607C3AD00815 CRC64;
MSGTVSILQQ FANGLKSRSE ETRAKAAKDL QHYVTMELRE MSQEESTRFY DQLNHHIFEL
VSSSDANERK GGILAIASLI GVEGGNATRI GRFANYLRNL LPSNDPVVME MASKAIGRLA
MAGDTFTAEY VEFEVKRALE WLGADRNEGR RHAAVLVLRE LAISVPTFFF QQVQPFFDNI
FVAVWDPKQA IREGAVSALR ACLILTTQRE PKEMQKPQWY RHTYEEAEKG FDETLAKEKG
MNRDDRIHGA LLILNELVRI SSMEGERLRE EMEEITQQQL VHDKYCKDLM GFSTKPRHIT
PFTSFQSLQP SQSNALAGLL GYNAHQGIMG FATSPVPAKS TLVESRCCRD LMEEKFDQVS
AQSCLSKFTA PVPVIAQSVS FQVCQWVLKC RTSKNSLIQM TVLNLLPRLA AFRPSAFTAD
QYLPDTMNHV LSCVKKEKER TAAFQALGLL SVAVRSEFQA YLPKVLEIIK AALPPKDFAH
KRQKSVQVDA TVFTCISMLA RAMGPSIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ
LKKDIQDGLL KMLSLVLMHK PLRHPGMPKG LAHQLASPSL TNIPEASDVG SITLALRTLG
SFEFEGHSLT QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ
VVADVLSKLL VVGITDPDPD IRFCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL
AICTVGRLSS MNPAFVMPFL RKMLIQILTE LEHSGVGRIK EQSARMLGHL VSNAPRLIRP
YMEPILKALI VKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FIIIMDMLQD
SSLLAKRQVA LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL
LGALDPYKHK VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV
SMVALMRIFR DQSLSQHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE
FLFQQLGMLV SFVRSHIRPY MDEIVTLMRD FWVMNNSIQS TIILLIEQIV VALGGEFKLY
LPQLIPHMLR VFMHDNSQSR IVSVKLLNAI QLFGANLDDY LHLLLPPIVK LFDAPDAPVV
ARKAALETVD RLTESLDFTD YASRIIHPIV RTLDQSPELR TTAMDTLSSL VFQLGKKYQI
FIPMVNKVLV RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSN QGETLASGPV
ETGPMKKLHV STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY
NPMARDLFNA AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDK
//
