ID A0A226NDT5_CALSU Unreviewed; 411 AA.
AC A0A226NDT5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=CTP synthase 2 {ECO:0000256|ARBA:ARBA00039648};
DE AltName: Full=CTP synthetase 2 {ECO:0000256|ARBA:ARBA00042715};
DE AltName: Full=UTP--ammonia ligase 2 {ECO:0000256|ARBA:ARBA00042374};
GN ORFNames=ASZ78_008541 {ECO:0000313|EMBL:OXB65510.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB65510.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB65510.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB65510.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB65510.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with
CC either L-glutamine or ammonia as the source of nitrogen. Constitutes
CC the rate-limiting enzyme in the synthesis of cytosine nucleotides.
CC {ECO:0000256|ARBA:ARBA00037348}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB65510.1}.
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DR EMBL; MCFN01000091; OXB65510.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A226NDT5; -.
DR STRING; 9009.A0A226NDT5; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0003883; F:CTP synthase activity; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:InterPro.
DR CDD; cd03113; CTPS_N; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR004468; CTP_synthase.
DR InterPro; IPR017456; CTP_synthase_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11550; CTP SYNTHASE; 1.
DR PANTHER; PTHR11550:SF2; CTP SYNTHASE 2; 1.
DR Pfam; PF06418; CTP_synth_N; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Reference proteome {ECO:0000313|Proteomes:UP000198323}.
FT DOMAIN 2..146
FT /note="CTP synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06418"
FT DOMAIN 189..318
FT /note="CTP synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06418"
SQ SEQUENCE 411 AA; 46582 MW; 0CD32249A470697A CRC64;
MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF SPYEHGEVFV
LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK ERHGDYLGKT VQVVPHITDA
VQEWVMNQAK VPVDDDRKEP QICVIEASIQ PLRHAYTFLL PSLFKCVREK LFKKYSSLLY
ILPLTDSSFL FQLGGTIGDI EGMPFVEAFR QFQFKAKREN FCNIHVSLVP QPNATGEQKT
KPTQNSVRAL RGLGLSPDLI VCRSAKPIEM AVKEKISMFC HVEPEQVIFI HDVSSTYRVP
ILLEEQGITK YFKQRLNLPI DDQPSDLLMK WKKMADRYER LLKVCSIALV GKYTKLSDCY
ASVFKALEHS ALAINHKLDL MYIDSTELER STEVENSVKY HQAWHKLCKA E
//
