ID A0A226NFK8_CALSU Unreviewed; 2526 AA.
AC A0A226NFK8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=ASZ78_000687 {ECO:0000313|EMBL:OXB66262.1};
OS Callipepla squamata (Scaled quail).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC Callipepla.
OX NCBI_TaxID=9009 {ECO:0000313|EMBL:OXB66262.1, ECO:0000313|Proteomes:UP000198323};
RN [1] {ECO:0000313|EMBL:OXB66262.1, ECO:0000313|Proteomes:UP000198323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texas {ECO:0000313|EMBL:OXB66262.1,
RC ECO:0000313|Proteomes:UP000198323};
RC TISSUE=Leg muscle {ECO:0000313|EMBL:OXB66262.1};
RA Oldeschulte D.L., Halley Y.A., Bhattarai E.K., Brashear W.A., Hill J.,
RA Metz R.P., Johnson C.D., Rollins D., Peterson M.J., Bickhart D.M.,
RA Decker J.E., Seabury C.M.;
RT "Disparate Historic Effective Population Sizes Predicted by Modern Levels
RT of Genome Diversity for the Scaled Quail (Callipepla squamata) and the
RT Northern Bobwhite (Colinus virginianus): Inferences from First and Second
RT Generation Draft Genome Assemblies for Sympatric New World Quail.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXB66262.1}.
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DR EMBL; MCFN01000068; OXB66262.1; -; Genomic_DNA.
DR STRING; 9009.A0A226NFK8; -.
DR Proteomes; UP000198323; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12793; RasGAP_plexin_B1; 1.
DR CDD; cd11275; Sema_plexin_B1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF36; PLEXIN-B1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000198323};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..2526
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011991191"
FT TRANSMEM 1473..1493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..488
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 2161..2523
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 755..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2134..2155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 2270
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2526 AA; 281385 MW; 71A25CB4D06DDA0B CRC64;
MPLGTFLLPV LCFLGVAIPR GLQYVTFSRN ATKFLHLSMD VESGTIYLGA TNFLFQLTSD
LLMKNVVQTG PVLDSKDCLP PVSKLECPQA HHTDNHNKLL LVNSVQKELI VCGSVHQGIC
EKRSLTSIDH VLFRPESPGD TQYVAANDPN ITTVGLVAYS KDEVPLLFVG RGYTSRGVGG
GIPPITTRNL RAHSSDVQAT DSHSIFSYEE TAKLAVGRLS EYNHHFIKSF TYRSSVYFLF
YRRDLKSQSR EYKTYISRIC LDDSHYYSYV ELPLLCQSKT NTYSLLQAAY VTQPGKDLAQ
GQLDTDGEVL FAAFSAWQAS SGKLSEESAL CVYTMEEVDR LTNWTRDVCY MRDGKSEDGT
EVAYIEYDVS SNCVQLPSDT LYAYPCGSDH TPSPMASRVP LKAAPLLETA EARLTAVAVN
VEDGHTIAFL GDSRGRLHKV YIGAMGDAHV YASLAIQLNS MVSGDLLFDH LQEHLFVMTQ
SMVLKVPILE CSLYSDCESC LALKDPYCGW CVLQGRCSRR SECLWTGLSE QWLWSFNSSQ
QCLSVQSLTP ANISREEKRN IFLAISDLPS LREEEFYSCY FQDYESPAVL TESGIMCPSP
DPNQTPALPA GAALGRVAVM SCISVAAAFL SLFQVPEVCE QFLGVQLAQI PTSSVFSSSA
APLTKSSTMA PAVAVKPITP PVHAVPSTVP PTEPNHITFS AASDSMTEPT ETISNPYSTL
STEAASLQAI TEPPLPPPAD KPAVTLPATA SPAASILTSP AKNVDRTASP TIGPSTAQEP
WHTEPPTTVA ATPLFTSSPA VTPSPHVTSF RWPLTSFPTT EAIPSPQTPS QMPDEPSASN
DSPAMLGTEI PASEPPPSAP HDWLPREDTE LQDTEDWMDL LKAENDTSPF SASTLLSGDG
DSSERDIPDL PRILHPDLDY QYDAPGFWED QQWDYECVLN LEGKTMMMEA YVEGDEADQS
LCYITCQLNQ HSYTAPQLEF NAVVFVQRRR HLRVDSAADL HVTFYNCSVG HTDCSRCQTA
DSKYSCVWCG GDKPSCIFRG SCKEEIEDLC PAPLIHSVYP LSGPVEGGTR ITITGSNLGQ
KHQDIAETVT VAGIPCAVNA QEYEISSSIV CVTGGSWTER IGHIVVEVPG GGRGISEHVF
TYQNPELKSI VPTQGPKAGG TCLTLLGSKL LTGHPNEISV LLGDLPCHIL SEMTEDQLAC
QTSPSNVSTE LPVTIKYGDQ ERRLEGSLFR YTLDPNITFA EPPKSFLSGG RVLRVHGYNL
DVVQSPKIRV TVSPSERRRR GLGRWRRIIP DTECPEDALC SIQQFEEPCL VNSSYLILCK
TPAINLLLRS VHIKLEFILD NLSFDFNSLH PMPFSYEVNP ILKPLNAEDP AKPYRHKPGS
VISVEGENLD LAISKDEVMA MIGEGICVVK TLTRNHLYCE PPSEQPAPRH RTKREGTDLL
PEFTVQMGNL NFLLGRVQYD TESPLTFPLE AQIGLGVGAS FVALIVLVIV FIYRRKSKQA
LRDYKKVQIQ LENLETSVRD RCKKEFTDLM TEMMDLTSDL VGTGIPFLDY KSYAERIFFP
GHRESPLQRD LDIPECRRQT VEQGLVQLSN LLNSKLFLTK FIHTLEIQRT FSPRDRAYVA
SLLTVSLHGK LEYFTDILKT LLNDLVEQYV AKNPKLMLRS SILAVHYIHV TNPMVSFRTE
TVVEKLLTNW MSICLYAFVR DSVGEPLYML FRGIKHQVDK GPVDWVTGKA KYTLNDNRLL
REDLEYRTLT LNALTQAGVA AGGAEDSQGI SAKVLDCDTI TQVKEKILDQ IYKGMPYCHR
PDPDTLDLEW RSGLAGHLIL SDEDVTSVVQ GTWKRLNTLQ HYKVPDGATV ALVPRLTKHI
HRENQDYIPG EKTPMLEDAD EGGIKLWHLV KPTEEPELPK HRRGSLRDRE RAKAIPEIYL
TRLLSMKGTL QKFVDDLFQV ILSTSRPVPL AVKYFFDLLD EQALHYGIAD PETIHIWKTN
SLPLRFWINI IKNPQFVFDV QTSDNVDAVL LVIAQTFMDS CTIADHKLGR DSPINKLLYA
RDIPRYKQMV ERYYADIRQT ISASDQEMNS ALAELSRNYS GDLNSLVALH ELYKYINKYY
DQLVPIALPP AHVRVRALSQ PGNSVSLLRD AEEFDQPKDN PPREYSPKAE QDQLVSHSLE
LQHEPDDERG GIPCLLNCME LNAGDCTAYA AQPSSPLLLS PLTRTCWDSA MEEWVQQDVL
EEQHTGGHHP VQEGEVFNAR YQALRELGCG AFATVWLCQD MRKKKNVAVK VLKSREGFAE
AAQDELSLLR CVLAGLHFLH GRCRIIHTDI KPENVLLYVH DKNLQRFLLD AVDCGQRTDL
RLKAPGGDPG NPLEDSDLMS IEVKIADLGS ACWTYKPFSK EIQTQPYRAL EVLLGLDYGT
PADIWSTGCL AFEMATGECL FNPQPGKYFS RDDDHVARII ELLGRIPPQI AFSWKKSTKF
FRRPGALLRI SRLVPRSLHA VLLDRLQRRA HEVPPFTSFL LSALRYAPER RPTAAQCLQH
AWLSAP
//
