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Database: UniProt
Entry: A0A226NV24_COLVI
LinkDB: A0A226NV24_COLVI
Original site: A0A226NV24_COLVI 
ID   A0A226NV24_COLVI        Unreviewed;       580 AA.
AC   A0A226NV24;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   31-JUL-2019, entry version 10.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   ORFNames=H355_012744 {ECO:0000313|EMBL:OXB71338.1};
OS   Colinus virginianus (Northern bobwhite) (Tetrao virginianus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Odontophoridae; Colinus.
OX   NCBI_TaxID=9014 {ECO:0000313|EMBL:OXB71338.1, ECO:0000313|Proteomes:UP000198419};
RN   [1] {ECO:0000313|EMBL:OXB71338.1, ECO:0000313|Proteomes:UP000198419}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texas {ECO:0000313|EMBL:OXB71338.1,
RC   ECO:0000313|Proteomes:UP000198419};
RX   PubMed=24621616;
RA   Halley Y.A., Dowd S.E., Decker J.E., Seabury P.M., Bhattarai E.,
RA   Johnson C.D., Rollins D., Tizard I.R., Brightsmith D.J.,
RA   Peterson M.J., Taylor J.F., Seabury C.M.;
RT   "A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus
RT   virginianus) Reveals Evidence for a Rapid Decline in Effective
RT   Population Size Beginning in the Late Pleistocene.";
RL   PLoS ONE 9:E90240-E90240(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OXB71338.1}.
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DR   EMBL; AWGT02000515; OXB71338.1; -; Genomic_DNA.
DR   Proteomes; UP000198419; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR031674; DUF4714.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR027260; Hyaluronidase-3.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   PANTHER; PTHR11769:SF19; PTHR11769:SF19; 1.
DR   Pfam; PF15833; DUF4714; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198419};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198419};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    580       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012669078.
FT   TRANSMEM    515    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   REGION      415    449       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    423    437       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   580 AA;  63997 MW;  6AD61D3460C19C54 CRC64;
     MGMGPALALW AWLVLGTTGR ESPAPAALAG GQPFAVLWNI PSSRCQRRFG VGLPLSDYSI
     VENQGGRFAG QNITIFYKNK FGLYPYISLQ GIPHNGGIPQ RAPLQAHLAR VAGDVRLRLH
     PAFSGLAVVD WEEWRPLWAQ NWGSKRIYQL ASQRWAQQRG RGRRQARRAF ERAARALMEQ
     TLLLGRSLRP AGLWGFYRFP DCFNGNWAKV ANYTGRCRPT EVRRNDHLRW LWAASAALYP
     SIYLPPLLPP GLRRRYVHHR LREALRVAIG RLPVVAYSRL SYRRSPRFLE PADLEHTIGE
     SAALGAAGVV LWGDLSYSRS AESCSSLRHY LVSTLGPYVA NVTAAAQACS SEQCQGHGRC
     VRRQPQELGS MLHLGVGTWA PFRCHCYRGW AGQDCTQPEL LSPTACPAPA HSLYRHRSPQ
     APDTCPRRSS WSWAEGTVPS EPTDPDGMDP GAISLHPVAS ISDLHWASAG YKGIEGNGPA
     PSSSRLRCAP HSPPHLPTLR PVPPPTICPC PGHPFFFILL GLLALASLIL ATLAIYLSVL
     QSQSVQALAQ WLESQEDAMR QLRAASGQLW ARLNASAQHH
//
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