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Database: UniProt
Entry: A0A226NV74_COLVI
LinkDB: A0A226NV74_COLVI
Original site: A0A226NV74_COLVI 
ID   A0A226NV74_COLVI        Unreviewed;       595 AA.
AC   A0A226NV74;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   13-FEB-2019, entry version 7.
DE   RecName: Full=Hyaluronidase {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
GN   ORFNames=H355_016719 {ECO:0000313|EMBL:OXB71388.1};
OS   Colinus virginianus (Northern bobwhite) (Tetrao virginianus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Odontophoridae; Colinus.
OX   NCBI_TaxID=9014 {ECO:0000313|EMBL:OXB71388.1, ECO:0000313|Proteomes:UP000198419};
RN   [1] {ECO:0000313|EMBL:OXB71388.1, ECO:0000313|Proteomes:UP000198419}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texas {ECO:0000313|EMBL:OXB71388.1,
RC   ECO:0000313|Proteomes:UP000198419};
RX   PubMed=24621616;
RA   Halley Y.A., Dowd S.E., Decker J.E., Seabury P.M., Bhattarai E.,
RA   Johnson C.D., Rollins D., Tizard I.R., Brightsmith D.J.,
RA   Peterson M.J., Taylor J.F., Seabury C.M.;
RT   "A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus
RT   virginianus) Reveals Evidence for a Rapid Decline in Effective
RT   Population Size Beginning in the Late Pleistocene.";
RL   PLoS ONE 9:E90240-E90240(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|PIRNR:PIRNR038193,
CC         ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OXB71388.1}.
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DR   EMBL; AWGT02000487; OXB71388.1; -; Genomic_DNA.
DR   Proteomes; UP000198419; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR001439; Hyaluronidase_PH20/Hyal5.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PIRSF; PIRSF500773; Hyaluronidase_PH20_Hyal5; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198419};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR038193,
KW   ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR038193,
KW   ECO:0000256|RuleBase:RU610713}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198419};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     12     32       Helical. {ECO:0000256|SAM:Phobius}.
FT   ACT_SITE    150    150       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    373    373       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     61    356       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    226    242       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    381    392       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    386    440       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    442    448       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   595 AA;  67826 MW;  9ED426E64F42BD27 CRC64;
     METLRQIQNF GICVTCTYPI ASGMVFTILL VSCCSSLNIR ARPLLSNSPF LSIWNAPTEL
     CTERTGVKLD MSFFSLIGST LKTSIGQNIT LFYPDRLGYY PYKNEITGEA FNGGLPQLAL
     LENHLKKAKE DIQFYIPSDE QFGLAVIDWE NWRPVWIRNW GSKDIYRQES IELVQQRDLS
     LSEPEARTIA KMEFEAAAKA LMLESLKLGI AMKPNRLWGF YLYPDCYNYD YKQNPRNYTG
     TCLDIEIARN NELNWLWEKS TALYPSVYLE TALRSSRNAR LFVRNRVQEA IRVSHVSNST
     HPLPVFVYTR PVFTDFYEEY LSQDDLVNTI GESAALGASG IVIWGDMNLT QNKNTCRTLD
     NYLRKTLTPY LINVTMAARI CSQVVCQDSG ACVRKKWNSS DYLHLNPENI VIRMTKDGKY
     TLQGEPAFQD LKTFIEKFEC HCYAGHNCEP RVDINNIHFL RACISEEICI QISSNSLSSI
     ESSKEKNLSN RTVFPLASQS KVTLSTHPEI EDFQSATGNT ILHITTAEYN TVIASTRYDT
     ECPSSTCTNF AKIFIKTLFL YLKNLDMAFC VAYCETPKDT DTLTRDGCWL SQSLN
//
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