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Database: UniProt
Entry: A0A226P7B6_COLVI
LinkDB: A0A226P7B6_COLVI
Original site: A0A226P7B6_COLVI 
ID   A0A226P7B6_COLVI        Unreviewed;       388 AA.
AC   A0A226P7B6;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   11-DEC-2019, entry version 11.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OXB75594.1};
GN   ORFNames=H355_015710 {ECO:0000313|EMBL:OXB75594.1};
OS   Colinus virginianus (Northern bobwhite) (Tetrao virginianus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Odontophoridae;
OC   Colinus.
OX   NCBI_TaxID=9014 {ECO:0000313|EMBL:OXB75594.1, ECO:0000313|Proteomes:UP000198419};
RN   [1] {ECO:0000313|EMBL:OXB75594.1, ECO:0000313|Proteomes:UP000198419}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texas {ECO:0000313|EMBL:OXB75594.1,
RC   ECO:0000313|Proteomes:UP000198419};
RX   PubMed=24621616;
RA   Halley Y.A., Dowd S.E., Decker J.E., Seabury P.M., Bhattarai E.,
RA   Johnson C.D., Rollins D., Tizard I.R., Brightsmith D.J., Peterson M.J.,
RA   Taylor J.F., Seabury C.M.;
RT   "A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus
RT   virginianus) Reveals Evidence for a Rapid Decline in Effective Population
RT   Size Beginning in the Late Pleistocene.";
RL   PLoS ONE 9:E90240-E90240(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXB75594.1}.
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DR   EMBL; AWGT02000141; OXB75594.1; -; Genomic_DNA.
DR   Proteomes; UP000198419; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003271; K_chnl_inward-rec_Kir2.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 2.
DR   PANTHER; PTHR11767:SF43; PTHR11767:SF43; 2.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 2.
DR   PRINTS; PR01324; KIR21CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198419};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM        83..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        123..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..47
FT                   /note="IRK_N"
FT                   /evidence="ECO:0000259|Pfam:PF08466"
FT   DOMAIN          48..124
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          154..326
FT                   /note="IRK_C"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   REGION          347..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            133
FT                   /note="Role in the control of polyamine-mediated channel
FT                   gating and in the blocking by intracellular magnesium"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005465-1"
SQ   SEQUENCE   388 AA;  44223 MW;  A6A047379AB398E7 CRC64;
     MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN
     VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL TFILSWLFFG CVFWLIALLH GDLENQENNK
     PCVSQSIVGC IIDAFIIGAV MAKMAKPKKR NETLVFSHNA VVAMRDGKLC LMWRVGNLRK
     SHLVEAHVRA QLLKSRITSE GEYIPLDQID INVGFDSGID RIFLVSPITI VHEIDEDSPL
     YDLSKQDMDN ADFEIVVILE GMVEATAMTT QCRSSYLANE ILWGHRYEPV LFEEKNYYKV
     DYSRFHKTYE VPNTPICSAR DLAEKKYILS NANSFCYENE VALTSKEEEE IDTGVPESTS
     TDTHPDMDHH NQAGVPLEPR PLRRESEI
//
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