ID A0A229FXG2_9BURK Unreviewed; 266 AA.
AC A0A229FXG2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN ORFNames=AOC33_04540 {ECO:0000313|EMBL:OXL16340.1};
OS Polynucleobacter cosmopolitanus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Polynucleobacter.
OX NCBI_TaxID=351345 {ECO:0000313|EMBL:OXL16340.1, ECO:0000313|Proteomes:UP000215188};
RN [1] {ECO:0000313|EMBL:OXL16340.1, ECO:0000313|Proteomes:UP000215188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MWH-MoIso2 {ECO:0000313|EMBL:OXL16340.1,
RC ECO:0000313|Proteomes:UP000215188};
RA Hahn M.W.;
RT "Reclassification of a Polynucleobacter cosmopolitanus strain isolated from
RT tropical Lake Victoria as Polynucleobacter victoriensis comb. nov.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC Evidence={ECO:0000256|ARBA:ARBA00000783,
CC ECO:0000256|RuleBase:RU366031};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXL16340.1}.
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DR EMBL; NJGG01000001; OXL16340.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A229FXG2; -.
DR OrthoDB; 9787650at2; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000215188; Unassembled WGS sequence.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU366031}.
FT DOMAIN 30..242
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 266 AA; 29918 MW; B3237A65A418AB67 CRC64;
MPTIVLTRPL GQSLRLGELL HRKFPMLEQI QLPLLSIVPN ENPVDAKRLK ELLLTTDLAV
FVSPNAIECS MRLLQEEWPK NIPVAVVGGG SLETLSHHGI TAQHDYTIYS PSNPSEWDSE
GLWKILNQSQ ASWAGKKILF LKGMGGRAWL GEQFLLQGAE IHSVLTYKRV PLVDDSPAWL
GLKKSIPSDS ICLMTSSEAA RHFAQFLKEN SSWAMSWLNE AMMLCTHERI TQVCTELGFK
NIDQCAPGDD QLLVKIDQWY VNKIRN
//
