ID A0A229TAS7_9PSEU Unreviewed; 2085 AA.
AC A0A229TAS7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CF165_12640 {ECO:0000313|EMBL:OXM68366.1};
OS Amycolatopsis vastitatis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1905142 {ECO:0000313|EMBL:OXM68366.1, ECO:0000313|Proteomes:UP000215199};
RN [1] {ECO:0000313|Proteomes:UP000215199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H5 {ECO:0000313|Proteomes:UP000215199};
RA Adamek M., Alanjary M., Sales-Ortells H., Goodfellow M., Bull A.T.,
RA Kalinowski J., Ziemert N.;
RT "Comparative genome mining reveals phylogenetic distribution patterns of
RT secondary metabolites in Amycolatopsis.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXM68366.1}.
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DR EMBL; NMUL01000010; OXM68366.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000215199; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 497..571
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1519..1593
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2085 AA; 219609 MW; 27E48CAFF2B96448 CRC64;
MNSAAHPTPT VPELVARRVD RTPGAVAVVD GDRVLTYQAL DELAGRLAAR LIGRGVRRGG
RVAVMLDRSA DLVVALLAVW KAGAAYVPVD AGYPAPRVAF MAADSGVSLM VCSAATRGGV
PEGIEPIVVT DEEDGEAATA AARPGDPAYV MYTSGSTGTP KGVTVPHRSV AELAGNPGWA
VEPDDAVLVH APHAFDASLF EIWVPLVSGA RLVIAGPGQV DARRLREAIA AGVTRAHLTA
GSFRAVAEES PESFTGLREV LTGGDLVPAH AVARVRAACP GVRVRHLYGP TETTLCATWH
VLEPGDALGP VLPIGRPLPG RRAQVLDDSL RPVAPGVVGE LYLSGAGLAD GYLDRAALTA
ERFVADPSRP GERMYRTGDL AQRTADGELL FAGRADDQVK IRGFRVEPGE VEAALTAQPG
VHESVVVAID GRLIAYVVAD EDTDPVLVRE RLEAVLPEHL VPAAVLRLAA LPLTANGKVD
RAALPAPDFA AKATGRAPAT EAERVLCGLF ADLLGVAGAG VDDGFFELGG DSIVATRLAA
RAAKAGLLVT PSQVFAERTP ARLAAVAGAV PAGSPVEGAP VVLTAQEEAE LAIAVPGAED
VWPLAPLQAG LFFESSLEDK GPDIYQTQWI VELTGPLDVP RLRAVWEAVF ARHAELRLSF
HRLASGKTVQ AVAGNVTLPW REVDLTGAAD AEAAVDALAR REQQERFDLA KAPLFRLVLA
RLGDDRHRLL VVNHHILTDG WSVAVVLNEV AEAYAAGGRF PDRSGAASYR DYLGWLDRQD
KDAAVEAWRA ELSGVGEPGL IAKTAAGTDD GYGYRVTHLP PDLYARLLEF TRDHGLTLNT
VVQGAWAMVL ARLARRTDVV FGTTVALRPA ELPGVESMPG LLMNTVPVRV PLEAGQPVLD
MLTGLQHRQV ALMPHQHLGL PEIQKAGGPG AVFDTLLVFE NYPRDFAEGF RYLGTIEGTH
YPVTLGIIPG DRCRIQLGYR PGQVDRTVAD SVLGWFVGAL EQVAADPSRP VGRVAVGAGT
VHRPVPALLA GESLPALIGR VAASRPADVA VIDADGELSY GQLWDRAVRF AAVLRDRGVG
PESRVGLVVG RSSWWLVGML GVSLTGGVFV PVDPAYPDER KSWIFRSADP MSVVCAGKTR
AAVPGEFADR LVVIDELDLA DVPEADLPRV GPRDAAYVIY TSGSTGTPKG VVVTHSGLGN
LAMAHIDRFG VTPSSRVLQF AALGFDTIVS EVMMALLSGA TLVMPPEQDL PPRVSLAETL
ERWDITHVKA PPSVLGTVDA LPSRLETVVA AGELCPPGLV DRLSAGRRMI NAYGPTETTI
CATMSMPLSP GQDPIPFGKP VPGVRGYLLD AFLRPLPPGI TGELYLAGIG VARGYLGRPA
LTAERFVADP FVPGERMYRT GDLAYWTDEG ELVSAGRADD QVKIRGFRVE PREIEFALSG
YPRITQAAVT VREDRLLAYV TPADIDTQAV REDLASRLPQ YMVPAAVVAL DALPLTAHGK
IDRRALPDPD FTAGAPARTP ATEAERVLCG LFAELLGLER VGVDDSFFEL GGDSILAMQL
AARARHTGLT FAAADVFDGR TPERIAQLAG SPLLEPAPSP QADGVGEIPW TPVMSVLGDG
VVGPRFAQWV VVGAPPELTE EALVTGAAAL VDTHDVLRAR VVDDAAGRRL VVGERGSVDV
RGAVTRVEAG DGSPDEVAEE AARDAVGRLD PAAGVMLQVV WVDAGPGGPG RLVVVVHHLA
VDGVSWRVLL PDLRTACEAA AAGREPALEP VGVSFRRWAG LLAEWAVSAE RVGELAAWKA
IVGADQPVGA RGLTVGGDAA GAVRSRSWAV PKAETSVLVG RAPVVFHCGV HEVLLAGLAG
AVTRWRGGDE VLVDVESHGR HPAGGMDLSR TVGWFTSVHP VRLDLAGIDP ADVLAGGPAA
GRLLKAVKEQ SRAVPGDGLG YGLLRHLNAE TGPVLAELPS PRIGFNYMGR FVTGDGNDVR
AWQPVGDIGS SLEPGMGLPH ALEVNAIVQD TPDGPVLTLM AEWPEGSLGD GEIERLGQAW
LDTLSGLARQ ADDPSAGGHT ASDFDLLDLD QDEVEEFEAI AAELQ
//
