ID A0A229TJU5_9PSEU Unreviewed; 510 AA.
AC A0A229TJU5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=CF165_00140 {ECO:0000313|EMBL:OXM71515.1};
OS Amycolatopsis vastitatis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=1905142 {ECO:0000313|EMBL:OXM71515.1, ECO:0000313|Proteomes:UP000215199};
RN [1] {ECO:0000313|Proteomes:UP000215199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H5 {ECO:0000313|Proteomes:UP000215199};
RA Adamek M., Alanjary M., Sales-Ortells H., Goodfellow M., Bull A.T.,
RA Kalinowski J., Ziemert N.;
RT "Comparative genome mining reveals phylogenetic distribution patterns of
RT secondary metabolites in Amycolatopsis.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXM71515.1}.
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DR EMBL; NMUL01000001; OXM71515.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A229TJU5; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000215199; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OXM71515.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OXM71515.1}.
FT DOMAIN 10..203
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 252..482
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 258..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 53411 MW; 57F1722888288B62 CRC64;
MTPARKTTGR VAFVGSGPGD AGLLTVRAQE LLAKAEVVVT DPDVPQAVLA MAAEGAEVRP
AVGEATEVAK DLTTEAKAGR LVLRLIAGDP LTTPAVVAEV QAVARTSAVF DVIPGVSPAA
AVPAYAGVAL GGTHTEVDVR GDVDWAALAA APGPLVLHAT SAHLAEAASA LTGNGVPAAT
PVAVTANGTI NTQRTLDTTL EKVANDAGEL VGPLIVTIGQ AAGQRSKLSW WESRALYGWK
VLVPRTKEQA GEMAERLRGH GATSHEVPTI SVEPPRSPAQ MERSVKGLVD GRYQWIVFTS
TNAVRAVWEK FEEFGLDARA FSGVKIACVG ESTAAKVRSF GIIPELVPSG EQSSEGLLAE
FPPYDDVLDP VDRVLLPRAD IATETLSAGL RERGWEIDDV TAYRTVRAAP PPAETREMIK
TGGFDAVCFT SSSTVRNLVG IAGKPHTRTL VACIGPKTAE TAVEFGLRVD VQPEKADVPH
LVDALAEHAA RLRAEGALPP PRKAKRARRS
//
