ID   A0A229VV99_9BIFI        Unreviewed;       881 AA.
AC   A0A229VV99;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=Tam10B_2299 {ECO:0000313|EMBL:OXM99552.1};
OS   Bifidobacterium vansinderenii.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=1984871 {ECO:0000313|EMBL:OXM99552.1, ECO:0000313|Proteomes:UP000215433};
RN   [1] {ECO:0000313|EMBL:OXM99552.1, ECO:0000313|Proteomes:UP000215433}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tam10B {ECO:0000313|EMBL:OXM99552.1,
RC   ECO:0000313|Proteomes:UP000215433};
RA   Lugli G.A., Duranti S., Mangifesta M.;
RT   "Bifidobacterium vansinderenii sp. nov.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXM99552.1}.
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DR   EMBL; NEWD01000038; OXM99552.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A229VV99; -.
DR   Proteomes; UP000215433; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OXM99552.1};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          23..476
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   881 AA;  94564 MW;  5F2C4609E305CF50 CRC64;
     MATKHKTKPS FDPRTVRENI VDTPLNEEMS RSFLEYAYSV IYARALPDAR DGLKPVQRRI
     IYQMGEMNLT PDRSYMKSAR VVGEVMGKLH PHGDSAIYEA MVRLAQPFAM RLPLVDGHGN
     FGSLDDGPAA SRYTEARLAP AALGMNADID EDTVGFRPNY DNKLQEPEVL PAAIPNLLVN
     GSSGIAVGMA TNMVTHNLGE VVAAAKYLMA HPDASVDDLM RYVPGPDLPG GGIIIGRDGI
     REAYENGRGS FVTRSVTHVE NITARKKGIV VTELPFMVGP EKVLERISEG VKSKKLEGIT
     GAIDLTDRHN GTRLVIEVKT GFNPEAVLAQ LFKHTPLQDS FTINNVALVD GRPHTMGLRE
     LLQVWIDHRR SVVRRRSAYR KRKAEERLHL VEGLLLALID IDEVIQVIRG SEDADAAKTR
     LMAVFELDDI QAQYILDLRL RRLTRMSRIE LEAERDDLRR RIEELDEILG SDERLDRVVT
     DEMDQAVAKW GTPRRTVLLD AAPSGELSPV HSEAATLSAG HAADTEAAIN GAKGMARATQ
     AAQQAAQAAQ HGVASLTISE EPCSVLLSAS GLIARSGESA LDALAARGPH TARGANDEIV
     SEFRTTTTSR YGLVTSAGRF VLAHVSDLPA LPATAEPNVS GGVAADELLT MTESTEPIAG
     EHVIAAVALD DDRPLAIGTR GGVIKRWNRE SPTTMDSWSV IDLKDGDVAL AAAPAADEDR
     LVFVSTDSSL LTFDAGNVRA QGRNSAGMAG IRLAEGCQVA AFAVVPAGRL AWTESETESG
     EVLYSGAVVL TVAGDSEALE GTENGSAKIT PLELYPTKGR GTGGVRSQRF LKGQDTLLLA
     RVGAWPLFAS AASGAPVALP SPDMRRDGSG VDLDSPIAIV A
//