ID   A0A229Z5D6_9EURO        Unreviewed;       412 AA.
AC   A0A229Z5D6;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=CDV55_107692 {ECO:0000313|EMBL:RHZ73103.1}, CFD26_109092
GN   {ECO:0000313|EMBL:RLM02001.1};
OS   Aspergillus turcosus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1245748 {ECO:0000313|EMBL:RHZ73103.1, ECO:0000313|Proteomes:UP000215394};
RN   [1] {ECO:0000313|Proteomes:UP000215289, ECO:0000313|Proteomes:UP000215394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMR AF 1038 {ECO:0000313|EMBL:RLM02001.1}, and HMR AF 23
RC   {ECO:0000313|EMBL:RHZ73103.1};
RA   Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA   Perkins V., De Repentigny L., Dufresne S.F.;
RT   "Draft genome sequences of two Aspergillus turcosus clinical strains
RT   isolated from bronchoalveolar lavage fluid: one azole-susceptible and the
RT   other azole-resistant.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RHZ73103.1}.
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DR   EMBL; NKHV02000010; RHZ73103.1; -; Genomic_DNA.
DR   EMBL; NIDN02000001; RLM02001.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A229Z5D6; -.
DR   STRING; 1245748.A0A229Z5D6; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000215289; Unassembled WGS sequence.
DR   Proteomes; UP000215394; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215289}.
FT   DOMAIN          14..321
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   412 AA;  45605 MW;  8E35EFD6010666D8 CRC64;
     MSQKRPTLEL GSVLVVGGCG FLGWHIVDQL LNFPSETDPS VALPKPEGDS RFDNPPLSGR
     YPRCVAKVSV LDLRTTNNRL PGAQYYDGDI TSEESLLAVF RAVKPDVVIH TATANVLEGN
     KELLHKVNVD GTKTLLEVAG GDRGDWGGKC KAFVYTSSAS VLHDTQSDLK NVNEDWPLIR
     GKLQLEYYSD TKAEAEEIVL KYNRASPSSM VTCSLRPAGI YGERDTAFTF KVLEHAAKSS
     PTVLRMQLGD NNNLFDFTYV GNVAYSHLLA AYHLLATQTR YEKGQGGPLD HEKVDGEAFN
     ITNDSPVYFW DMTRAAWALA GKVVEPDQVW QLPEDVLGPI GGMLEAVYGL FGKTPRLTRR
     MVRYSCMTRY YSCEKAKHRL GYSPIVSVPE GLSRGVGYVL ARERLESEKK AL
//