ID A0A231HKV7_9BURK Unreviewed; 759 AA.
AC A0A231HKV7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:OXR49436.1};
GN ORFNames=PuT2_06400 {ECO:0000313|EMBL:OXR49436.1};
OS Pusillimonas sp. T2.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Pusillimonas.
OX NCBI_TaxID=1548123 {ECO:0000313|EMBL:OXR49436.1, ECO:0000313|Proteomes:UP000216496};
RN [1] {ECO:0000313|EMBL:OXR49436.1, ECO:0000313|Proteomes:UP000216496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2 {ECO:0000313|EMBL:OXR49436.1,
RC ECO:0000313|Proteomes:UP000216496};
RA Yuan M., Qiu J.G., Ma Y.;
RT "The genome sequence of Pusillimonas sp. T2.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXR49436.1}.
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DR EMBL; NIQA01000003; OXR49436.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A231HKV7; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000216496; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:OXR49436.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000216496}.
FT DOMAIN 92..191
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 433..494
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 685..759
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 84110 MW; C35F7D51562F4BE6 CRC64;
MAFSSLRDAS TGLLAVFRKG PRLRRRAQKT KGRPGTAPEL ATPASPTIAS LAPLTQILAQ
YLDEKDIERV KEAYRFADQA HLGQFRSSGE PYISHPIAVT EICAGWKLDA DSLMAALLHD
VMEDQDVPKH ELAEKFSPDV AEIVDGLSKL DRLEFATKAE QQAESFRKML LAMSRDVRVI
LIKLADRLHN MRTLDAVSAE KRRRVARETM EIYTPIAHRL GLNALYRELQ DLCFQATYPN
RYDVIKKAVM AARGNRREVL GKITDAVKVA LPAAGIEAEV SGREKSLFGI YKKMLEQKKS
FSDVLDIYGF RVVVHTLPEC YLALGTLHQL YRPVPGKFKD YIAIPKLNGY QSLHTTLVGP
YGTPVEFQFR TRDMDRVAEE GVAAHWLYKN DDSNLNVLQK RTHQWLQSLL DIQSQTGDSG
EFLEHVKVDL FPDAVYVFTP QGKIVSLPRG ATPVDFAYSI HTDVGNQAIA SKINGEFSPL
RTELKSGDAV EIITSPASRP SAQWLNYVRT GRARSEIRHY LRTVKYEESV AFGRRLLMQA
FDQIGIDYPA DEDANWDKLA KSSGASSREE ILADIGLGKR LAAVVARRFA PENPILATTA
AAVDELTSAH AASIIIHGNE GQAVQLASCC GPLPGDAIVG GIRLGHGLVI HMADCPVAQR
QRAKEPERWV SVAWASDTAR HLNTRLDVTV INERGVLGRL AAEITDAGSN ITHLTMQDEA
TATGLLHLTV QVDSRKHLAQ VIRAIRHVPQ VQKIVRVKG
//