ID A0A231PGA5_9ACTN Unreviewed; 428 AA.
AC A0A231PGA5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245};
DE AltName: Full=Membrane protein YidC {ECO:0000256|ARBA:ARBA00031538};
GN ORFNames=CHR28_18715 {ECO:0000313|EMBL:OXS33714.1};
OS Streptomyces sp. XY006.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2021410 {ECO:0000313|EMBL:OXS33714.1, ECO:0000313|Proteomes:UP000215527};
RN [1] {ECO:0000313|EMBL:OXS33714.1, ECO:0000313|Proteomes:UP000215527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XY006 {ECO:0000313|EMBL:OXS33714.1,
RC ECO:0000313|Proteomes:UP000215527};
RA Shan W., Liu H., Zhou Y., Yu X.;
RT "Draft Genome Sequence of Streptomyces sp. XY006, an Endophyte Isolated
RT from Tea (Camellia sinensis).";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|ARBA:ARBA00025034}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration.
CC {ECO:0000256|ARBA:ARBA00026028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXS33714.1}.
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DR EMBL; NOKT01000015; OXS33714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A231PGA5; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000215527; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..255
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 331..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 47134 MW; 8766FAC90709CAD1 CRC64;
MDTIASLFSF ITTPVSWVIV QFHTVYGAIF GPDTGWAWGL SIVSLVILIR ICLIPLFVKQ
IKATRAMQTL QPEMKKIQER YKNDKQRQSE EMMKLYKETG TNPLSSCLPI LAQSPFFFAL
YHVLNSIASN DTIGVINNRL LESAQQAHIF GAPLAAKFTD SASKVEALGS SITDVRVVTA
IMIVLMSASQ FFTQRQLMTK NIDTTVKTPF MQQQKMLMYV FPVMFAVFGI NFPVGVLVYW
LTTNVWTMGQ QMYVIRNNPT PGSKAQAEYL ERLHKHVTHR DKVARRRDRV IVKAIVAKGR
DRNEYERKFI NGLSKAGLAA QADGTVIRSD AAAAAQAEDG TPATTGTPKR QQPKRQTKAQ
RQSGTVGGAK AAGEQEPKTS LTKSDEPEDA KPAAAAKKGG AKPAGGTRSK AQSGQRKGPQ
RPKSPSKK
//
