ID A0A231R3K5_9BACL Unreviewed; 823 AA.
AC A0A231R3K5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=B1A99_28995 {ECO:0000313|EMBL:OXS53690.1};
OS Cohnella sp. CIP 111063.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=1955714 {ECO:0000313|EMBL:OXS53690.1, ECO:0000313|Proteomes:UP000215193};
RN [1] {ECO:0000313|EMBL:OXS53690.1, ECO:0000313|Proteomes:UP000215193}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 111063 {ECO:0000313|EMBL:OXS53690.1,
RC ECO:0000313|Proteomes:UP000215193};
RA Dastager S.G., Neurgaonkar P.S., Dharne M.S.;
RT "Cohnella sp SGD-V74 (T) CIP 111063, whole genome shotgun sequencing
RT project.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXS53690.1}.
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DR EMBL; MWSG01000024; OXS53690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A231R3K5; -.
DR Proteomes; UP000215193; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OXS53690.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000215193};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 61..128
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 188..291
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 645..735
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
FT DOMAIN 740..821
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 823 AA; 95458 MW; 192C5E7696A27A73 CRC64;
MRELTLNGEW EMKRTDEAEW IGATVPGSVF QDLLAAGRME DPFFRDNEYE TLELTKFDYE
YRRSFFVDAE LLKHERVLLR CEGLDTLCEV SVNGRLVLQT NNMHRTYEAD VKETLSEGRN
DIVVVIRSAT NYVLARDREY HLTSCADAVP GISHLRKAHS MFGWDWGPKL PDMGIWRGLS
LLGCDGGRIE DVYVTQRHED DRVGLEIDAT LERWSEAAEL RLLATIDTPD GKRLEVSAER
AANTNRLTVD IAEPKLWWPN NLGDQPLYTL RIRLLSGERE LDERTMKLGL RTLRVQQTPD
QWGESFAFEI NGHEIFAMGA NFIPEDNVFG RRSEERMERL IRSCVEANYN CIRVWGGGYY
AEDYFYDLCD RYGLIVWQDH LYACGAYDFN DEFKENVRLE TVDNMKRIRH HASLGIWSGN
NELEYAWAYW GWTERYGEKL RDDYLEQFER FLPELSKSLD PNTFYWVSSP SSKGGIDDPN
NEHVGDMHYW DVWHGRKPIT EFRTLFPRFM SEFGLQSFPS LRTVETFTLP EDRNIFSRVM
EAHQKNGTGN EKIMYYVSEY FKYPKNFETL LYVSQLIQAE GMPVGVEHWR RHRGRCMGAI
YWQLNDIWPG ASWSSLDYYG RWKATHHAAR RFFSPVLASA CEEGTKVSLH VTNETLQPIA
GRLRWRLLDH RSAPIAAGEA EAELDALSTR EVVVLDFAET LSDSRQLRRS YLAFEWLADG
RTISSGTVLF VKPKHFDFLE PGIRLDATEE DDRFVVTATS RAFARFVLLE LDGADAEWSD
NVFDLSADRP HVVTVRKAGL SEPLDLKAFR ERLKATSLFD TFE
//