ID   A0A232EJN1_9HYME        Unreviewed;       799 AA.
AC   A0A232EJN1;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN   ORFNames=TSAR_014513 {ECO:0000313|EMBL:OXU18518.1};
OS   Trichomalopsis sarcophagae.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC   Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX   NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU18518.1, ECO:0000313|Proteomes:UP000215335};
RN   [1] {ECO:0000313|EMBL:OXU18518.1, ECO:0000313|Proteomes:UP000215335}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Alberta {ECO:0000313|EMBL:OXU18518.1,
RC   ECO:0000313|Proteomes:UP000215335};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OXU18518.1};
RX   PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA   Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT   "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL   Curr. Biol. 27:2007-2013(2017).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXU18518.1}.
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DR   EMBL; NNAY01003995; OXU18518.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A232EJN1; -.
DR   STRING; 543379.A0A232EJN1; -.
DR   Proteomes; UP000215335; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          426..657
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   799 AA;  92758 MW;  981A61B6CE565785 CRC64;
     MSLLKSQFTF EGAWPCMRPI ILKLLKQEPV TQGEWQDLFY SVHQVCLDEK GPPKLRDSLK
     EDIMDFIKQA QRRVMAHQEE QALLKAYIAE WQKFFTQCNY LPTPFRQLEA SLRGKTSSSM
     QKKNQPEESI VRKLMLDSWN QSIFNDIKQR LQDSAMRLVR TERNGEVFDS QLVIGVRESY
     VNLCSNPTDK LEIYRDNFEA AYIEETEAFY WVKAPEHLYM YGVEKYMRYA ETKLKEEELR
     AQKYLEPNSA SVQLLMERCV KVLVANFKTV ILSECPRMIQ QHQTEKLRLM LKLMDRVPEG
     VTPMLVDLED HIATAGLDDM MAAVDIITQD SEKYVERLLD LFRRFSNLVK EAFDDDPRFL
     TARDKAYKLV VNDSSVFKLD LPMRQGSGGA PAVASAAAAP LIGTITSLGG PNSKPVNNNN
     GLPESKCPEL LANYCDMLLR KTPLSKKLTS DEIESKLRDV LLVLKYVQNK DVFMRYHKAH
     LTRRLILDTS ADSEKEENMV EWLREVGMPA DYVNKLARMF QDVKVSQDLN QQFKEQCRAA
     IADSINIKIL NAGAWARGSE RVTVSLPLQL EDYIPEVEEF YKKKHSGRKL QWYHHMSNGT
     ITFSNQVGKF DVDVTTFQMA VLFAWNQRPL EKISYENLRL ATELPDPELR RTLWSICAFP
     KIKRQLIIAD PPAQSPKDFS QATKFWVNQE FAIIKNGKLQ KRGKINMIGR LQLSTERSKE
     EDNQSIVQLR ILRVQEAIIK ILKMRKKITN SQLQTELVDI LKNMFLPSKK MIKEQIEWLI
     EHKYIKRHDN DINTFVYMA
//