ID A0A232ET22_9HYME Unreviewed; 759 AA.
AC A0A232ET22;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=FYVE, RhoGEF and PH domain-containing protein 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=TSAR_004392 {ECO:0000313|EMBL:OXU21504.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU21504.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU21504.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU21504.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU21504.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU21504.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NNAY01002344; OXU21504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A232ET22; -.
DR STRING; 543379.A0A232ET22; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR CDD; cd13388; PH1_FGD1-4_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF241; PROTEIN CBG10230; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 213..401
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 430..528
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 549..606
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 637..741
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 37..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 86345 MW; 4A39D82502E33201 CRC64;
MLRGQLKDFT SWMACLRPEP FEPKMFGSKT SGTSTFYTDL HITDDKDSQP ASGESEKTGN
RNSRLLEQQS AASEDGNSQD SDSVGGQEEQ NQYPRHSFHR IASFGGFPRF RPFVMSTASA
VCTEVNTTQE TTIESSYTNM SHSVLEYRSS RYVVQESSYQ NDYAVSESES DEESEETRSS
ETDSAIVADH VDDLLADQRL RARKSSIEAK RKKARHIADE LLTTEKKYVN ILYLIDQIFQ
FRVDQENRAH PMFPPDTVQQ MFSNIKSIYK FHNDFLLPQL ETRIEAWDAD PRIGDIMKNF
APFLKMYTEY VKNFDYAINL ISTLQQKVPR FAAIINEIQK LDECAKLSLA HHMLSPIQRL
PRYELLLKDY LRNLVKDNPD YEDTKKALEL VSTAANHTNE AMKKIDKFKK LLEIQESIYD
STDLVSATRE LVKEGRIVKI SARSGDHQER HMFLFSDILL LCSLRLIPGP LYRLRAKFAI
ESLQVIEGDN LETANTFYLR GRNKSVELYT HSATEKAAWL DALFETMQEI MRRKASLKIG
NANTALLKAD DVTRCMVCEV IFSVMKRKHN CRACGIVVCS KCSNQKLLFE DNKNMRVCRL
CHAALTQPMS KSTSPSSPTT GSNGPVPSLL QVSAAAASVL SGYLLLKTQA SKPWTRRWFA
LHNDFVLYTF KTESERTAMT ATPMPGFTVT EGTDLPDEDA LNAKDRVRAF KIHHSRKSYY
LQASSQTDKE RWLNALQLAT KAELPQATDE VKDAQPESQ
//