ID A0A232EWD7_9HYME Unreviewed; 1688 AA.
AC A0A232EWD7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TSAR_000494 {ECO:0000313|EMBL:OXU22660.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU22660.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU22660.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU22660.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU22660.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU22660.1}.
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DR EMBL; NNAY01001878; OXU22660.1; -; Genomic_DNA.
DR STRING; 543379.A0A232EWD7; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22207; pseudoGTPaseD_p190RhoGAP; 1.
DR Gene3D; 1.10.10.440; FF domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF4; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 1.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 430..484
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 597..771
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 788..953
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1474..1679
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 961..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1245
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1688 AA; 193053 MW; FF6BBB067049ED8F CRC64;
MARKNDNVKY INVAVVGLSG TEKDKGQVGV GKSCLCNRFM RSLSDDYSVD HISVLSQSDF
SGRVVNNDHF LYWGEVVKPT EDGSADFQFQ VIEHTEFIDD ASFQPFKGGK MEPYAKRCAS
TKITSAEKLM YICKNQLGIE KEYEQKVLPD GKMNIDGFLC VFDVSVVPNR SIEKQVDIVA
NILNNLMKAK KPIVLVTTKN DDANEQYVKE AEKLLMRKEY KGSILMVETS AHENINVDLA
FMTLAQLIDK TKLRSKVIAF SEAARQRKEL MDASTESLQR LIRMHVQDYR AIWSQSSKKL
AQHREFTTFV ELFGIDATQR LFRRHIKKLK DEQIAKKIQG YLDMLPDILH EICPDISNLI
NEEWSNVQQY IKEHPDFDRY FYECPEDIPW IDYDFGENNT SKIPYDVLET PEAETVFKNH
VNALQQEQRR LEWKKQFKQL LEETGYVTPG KQLSEVRVLF MGRECFEALS HHDCQEIYEQ
HQKEITDKAR HNFQELLLEH ADLFYHYKSI APTGTITQDD IKEITDALLD DFRYKALDRL
DQDRKLMLFQ HLGFVHCPIR EHCPAFPNCM DALIERILST KAHRPSSWNH SSQWQLTSEN
NQLNLVILGN SGLSEEFARE IRSQTEDDEV EIDCQLYTLG YRVIDGDVGL PHNSFTTSDF
MPHGSFCIYS NEDTFEYVRS SLEKTLLSNL EQEDRLPFQG LPIVIIFVPD GVIDELEAMR
LREEGQNLAD SLQCPFIDVA VEDLEQDKRF PTSLVKDSLQ QLVQAINHRA GFLNIYQSVI
ECLEPDIRII MCMFCGDPYS VENVLAPLLS HQCCFLSSER SIVLETFLGD SKRRVEVTIS
SFHGANAFRD ELVHGFILVY STKRKASLAT LKYARIFAFS HNIPNLPIQI MAVTDTGGAN
AFFTNDLSHH LITEGNATAD KLQAHFMTSS SSCQQKTAFY TPFFKEVWEK KPEIEQAFNM
EEPGNLNDSG EGTLEYSALH PMPPPRHESY HLQTPDDGSG SESYEQLTPD GELGETGLNE
HFVDNRATPS DDSDIYSQVD YHREERDRDF GRGGDITSKL SGWVKETFMH QQQDGVTNNY
PHRSFTTGRR HISQTKSRPK GNSQTLKQPG KINLKDFSNV TDVISRMAIG EKDEHGKMSM
GHAPLATPEM VDLGSEYAQV KDVVPNIYPH YEGDYVYTLV HDSINNKSKL RHRREKGQPY
SPSTAYSDSD SEWSSLERQR VAEALGKANN KKTSSHKRTR KKRTAIPVAT PKVPSLAGMP
GSGGGMGNFG DGIVGLNYSM KDDKNWRVDP AERVSSESPD TSESSDQDQP WRTRTKIHTN
KHPAANLRKK FGNSLPPQVH LAQSLQHPFN LKHMTQEMFN TMTSKQQRTL VENNFTSMPD
DESSLDVSSP REINSPSFGL LTKNKDSQDK LTRKRDKQKA KEDEKIEKRR LKEEKLKRHA
EKEREREKKK QEKTKQTKGG SGGVNMSLQL MPQTLIEDFA QSETNPIPLF LEKCVKFIEE
EGLDSEGIYR VPGNRAHVEL LFQKFEEDGN VDIHSLDIPV NAVATALKDF FSKRLPPLID
KESMSQLEDI SGESLFLVHH TIANNIRLFC DRSGRLLALR MMLTKLNSIN FDVLKFIFQH
FVKVAENCKL NSMDSKNLAI CWWPTLLPIE FNDLGRFEAM RPYLEDVVQT MIDQYPFLFC
GKEAIVMV
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