ID A0A232EXU1_9HYME Unreviewed; 962 AA.
AC A0A232EXU1;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=TSAR_005840 {ECO:0000313|EMBL:OXU23274.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU23274.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU23274.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU23274.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU23274.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU23274.1}.
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DR EMBL; NNAY01001667; OXU23274.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A232EXU1; -.
DR STRING; 543379.A0A232EXU1; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335}.
FT DOMAIN 645..877
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 962 AA; 110233 MW; E9D36310D12A9A16 CRC64;
MENARIHKLL LAEYEELAGE KILVESPFAE TTRDGRGLGQ VALGLTRTKL LVATDVFRNN
ESYWCLPGID PSIETLELIS VYPLEFITVS VFRRRYRKVL KVRLRIEKCS APSAKQRAYS
VGKERRFCDG RAKYFELGGL ANRAKYWRRW RDQVRRLLER KCLGSSLSET TVAGNSTCAS
TCYLVSSGFE YDSGASGRCV RKRKRLYAGG DHTCGPTWTQ KDLYLGPGYQ ELMNGTYAPQ
RVRFADASLK EIKDELADCS PNKHKSCSVS NSRTRHLKSH QSGEICDVIY ARKNDRRSVD
QRLLAAAMKE SLEDQKSDLQ DMFQFKPDKN DLCRDQCPSV VLDIEEPGSD ILRNTCASRK
PSKIPRFNNK SKVKPKPRVE ARTGKIVRKL SRFGFGVEEK CNSGLCLGPY KNDPSASPPV
NFHELVENGV VVWENVRKCK DESAKKHLRR YGLSTATYFL HALGPWSVQP GDRESCQSRQ
RSNSCVTIRR QPVDPELRLP VSRRQLAASI SLTDLSGCSG LTASTRSRVV LFWTPDYWYR
PRAATDAYRE IRRHLGRLSQ FRAEREKGKV TRRSSVFGRK IKPRSRTNVK SCNPECQSTD
STTGSIINRI FSNQNHERSQ PPASGTFHLR RLLRLDFRVT LWDLDSTTLS RQLSLIDREL
FLRIPWRREL AILAKQRASR DAPNLGAWIA FAHRVACLTA SEILSAKKVD MRARLVARLV
NAAERCFLLG NFHSARSIVA GLQSPAVYRL KDTWTRLKSR HATRYETMEK LSKVFRSTRT
RRYRRAWSKA EASPPAMPFV GDVLARLLGL CDNADKPERT VTKAAVEKQR RPAIRQKGGL
RKWIPRIKLA LQLAIGIFLI QCLSQKRFRS PMREEEVSWT DHERQLAKRC CDHWRDRVKR
RRPTSLVDEL ADWLEGCQRQ TKQGYDFPGH SLAWEFLLKA RYREDRDNFF ASLQLEPPTA
CG
//
