ID A0A232F3D5_9HYME Unreviewed; 2820 AA.
AC A0A232F3D5;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=TSAR_000011 {ECO:0000313|EMBL:OXU25092.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU25092.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU25092.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU25092.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU25092.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU25092.1}.
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DR EMBL; NNAY01001115; OXU25092.1; -; Genomic_DNA.
DR STRING; 543379.A0A232F3D5; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1758..2355
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2459..2774
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2788..2820
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2745..2766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1439..1466
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2820 AA; 324835 MW; 23BCEE3395BB3EF3 CRC64;
MSCMDRLSQI ASLAKSKKVT DYKKAIKQLL EFWDDNSEIT LQPITEYSRD PTPNERYDFY
SWNDIFIIVH ELFINEIDRI SKLSGNAGKL DKERVTTLVF RTSEKANYYL KPKDVVNSTL
QLLRYGSLHI FSEYYEIYLH ILRKYVLQER SQRILLASKH WQELLNMCVS ILQKIIPNVD
YAKLLETIEL IVKYGCDLST LLFETRNLLP VIANILENYE PYKIKSADIL FKLTFTVCQQ
IATDSRLTLC KFSESIPLSM IDIKGPEEKY QLYLLFVQVH HPKGAILGKD GSYAYDNEKW
KAILNLLYKM ILNDLRSVLL SENFTLLACE VFRQKLLTNL PCFSHTNTFH DSIYIQPRKK
RRISDDQDKM IDLINDRDPK KAWPMIQITA ALYKKYPDCL KFEEFVEFLE TIIKLMKEAC
KTFAIMENLC ELATVLVQNE NTYNNKDSLQ IYWDKIWDAA LRYISMTHED VIQKGCLLVQ
NLISHKKISN PNALLKLYLT KSIQWSSLSI LTLKILCEYI VLPNEIKDCD MNSTLLTNNS
LKLQLMQWVL NTPTRRLTDP LSIEEFSKTL IGLTLKSWYK AHDYGFQDHF KKYYIDLDHN
LYDDQKTITI NDIERCYLSV NFETKLLVNN DSNKDTPLLN ENNLDNPYIV EDLDFLIHNL
MQMVQAEDSD KELSSFITKT SIIANIISNL QAMNMIQCNF DEFCLVNELK TCLSKIFDQI
ININWSKNIR ITLEITKALI SLYQTKYDVK VKDIILTSTQ FQNLKKIYDI SKIEIDEFEP
NTKSSLCIIN SITVLALYSC LDADGEISEL QMKIASTLLK LKKYSLSIKV DVICVVTMLE
IYSNIPNSVV TEEFGELLMT FVMDVFQSWH KDDKVNRCLL YFVPNILKKL VYIDENNVHI
HNVLTICKLY QEKFTKGVFG QMTHLSLVQC LNNIVKHTVF HNTGIEVLTY DVFTNFVNSC
NYLVRLECLN VIDSIFSNTN LSNTWKSEFF EKLNKTVYDV FLMQRQLSED EIQEERLLRS
TSAMQVLATV ICSKSTFQGP ALFTLARIIV DKDIEPSIVK KTLQIINASN PSTKCIVEEN
LNYILTAWCR VASFGKFPHG LLNCSTEMDF YDRYARAIFP VLLREGKMQE AKSFCERLGV
TFEQIFKTCS ANILPWALSD EAAKTLEQMQ NNQGNFEGIG KLGSIIKENL QHIIVQLVQR
LHDLRHFYKV FDSTIDLPES DPPHFKAEVI DACFDRLIRI INSDPRQSVF ACIILRKPSI
FQKILLQLTR NVYTSKISQY KAKAFHQYIY FCSKIAVELN ESYCDAVATY FVRDIGCTLL
NLTKEKDSFI TKLACKYMHK FFKGILPRRG AQVSNILSLC VKTLIPMIQD AKETSPLAKD
ILVLLLKERR ECLAEAIERL GTLSSFLRSS EDDDNPESQV LRENLKHFLS ASENKSCSVD
DLIALKRQLS SKREELEELY SELETCQGFA EHCARSVLHR LVYQLIRLTE SPDTRISLEA
AKCLGLLGPA DLCTMILHPQ ETQQRELIDK ANMLTHKVCW MLSEFVLSDD IELRSVSSEV
FYVVLDSTWG ARVGIDECAD SVENVAFLRE FLKPFRSSQK GHDANKVTKP QIDAVELERV
FDPQNPLWSE ASNDSYNKWL STITSEVARC LDNFYSKSLI PVFQLSVQFC ELTLQRLVSL
LIDVNSSLAK RICHCVNRFF EHHFKDDRID DQTLSPSTPP QMLQGCKARD AIRCMLIVVN
HLRIQTREQV TLDFDYLSIA MAAQFCSAYF SSVLYTELWC RSTLKLARDF DSIPIIDQIY
EQENRQGRIA QDILKEAYMK IGDSDSIHGC GSSHLHNHGS RIPYYTNFQK LDKLILSHDV
ELSINSSSAR GMVTALRESS LHHLAKRLLL SSTSMQVDPM DDLCYDSLWR LSDWSQIMSF
KASQSSSKEN DFSKSHYEAL KCLHENDNSS LQKNLEQAYF CVIKDLCNIS LESCRAVYPK
LSQLQMLREI EELSSSHSDD YEILLANWKK QQYIYNSNFQ YIEPILSQRA VMFKIREPIK
SSPIIKDALI DVHLETARLA QQQGHINVAA RSLETLSKVD LNNESGNRLL YHEALLAWTR
KDEDMARFNL RTLIKKDSIK PNLLARALRI YGNWIAENKS ENPQAIINKY YKKAIDTYES
IPTKLIQDEL RDNCKARAAL AQFAHEQYLV ITEYMKSPQF ESLMECLDYS RNAVLQKAPN
KNDRDVERAV QINTRQSSND SIEIENIQKD KAMYLAIAVE NYLSTLQDSD EHDFLVFRLV
SLWLDNTHDA QVNKRLENKL ALIPSYKFIP LIPQLAPHMN DNDQVFSLKI SQLLERCARD
HPHHTLPVLL ALKNLYNDSK YCGKKTVNEE PRVLGAQHLI QKLLSTDIRP IIQEMERLSD
ALVMLAYYES EKKAVSKCII PRNQALNNIK DFQHSIIPSI TISIKKNGKY NNIVSVRKYE
SSFGNVGGIN APKKIICTGT DGIARPQLVK GKDDLRQDAV MQQVFTVMNS LLRTKKDAKQ
RKLYVRTYKV MPLTQRSGVL EWCENTLPLS IILTGDGSPK AGLHQKYYPS DYTPNECRKR
LCNAKTAQQK YSTFMDCCKN LHPAFHHFFT ENYLSPETWF ERRLAYTRSV ATTSIIGYIL
GLGDRHVSNI LLDKSTAEVI HIDFGIAFEQ GKVLPTPETV PFRLTRDMEV AMGVSGVEGT
MRRCCEETMT VLREQREIIV TLLRVLLYDP LYSWAITPAK AATYQSEHSS RSSENKDSNS
SGTTETNKLA ERALLRVQQK LQGIEEGVTS SIAGQVERLI QQARDPTNLC KLFQGWQAYL
//
