ID A0A232F5E6_9HYME Unreviewed; 749 AA.
AC A0A232F5E6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Groucho/TLE N-terminal Q-rich domain-containing protein {ECO:0000259|Pfam:PF03920};
GN ORFNames=TSAR_006397 {ECO:0000313|EMBL:OXU26056.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU26056.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU26056.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU26056.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU26056.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU26056.1}.
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DR EMBL; NNAY01000888; OXU26056.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A232F5E6; -.
DR STRING; 543379.A0A232F5E6; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814:SF21; TRANSCRIPTION FACTOR UNC-37; 1.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1..100
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 549..590
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 591..632
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 673..704
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 135..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 80415 MW; 4468A5A429E08013 CRC64;
MKLECEKLAA ERIETHRHYV MYYEMSYGLN VEMHKQTEIS KRLNAIIAQI LPFLSQEHQQ
QVATAVDRAK QVTMTELNSI VGQQRPDIPR LLQQMQVQQL PPGAAIGPHP GMPGLPALGP
AAGLPVPTSA SALLGLGLTP GAPPTPGSTS SHPLSMLSKP ELHRNSQPDD AKSNGGLSST
EERHRSSISP GEKYIRPRSP QESHHGHHTQ NHHDHPIHIK KMKKEQDKDL GHSDGEKSDQ
DLVVDDASDC PTSPAVNGTT SPRENGIDKL GVSALGSSSN SNGNNGTTKK DLPPHSPRSS
TSSNASTPSA KKMEEREKAT TPISKPLTPT SAPSNSLKPS ASSKAGPLQG PPPPGSVPGA
YPAHYPPGPL HHLPPGSQHP AHVELMGYNG YAAPRAPPTL PQQLYDAHRV MGVGSVPGGK
PAYSFHVSND NVMVPVPFPP DALIGAGIPR HARQINTLTH GEVVCAVTIS NPTKYVYTGG
KGCVKVWDIS QPGGSSAKPV SQLDCLQRDN YIRSVKLLPD GRTLIVGGEA SQLSIWDLAS
PTPRIKAELT SSAPACYALA ISPDSKVCFS CCSDGNIAVW DLHNQTLVRQ FQGHTDGASC
IDISADGTKL WTGGLDNTVR SWDLREGRQL QQHDFSSQIF SLGYCPTGEW LAVGMENSNV
EVLHATKPDK YQLHLHESCV LSLRFASCGK WFVSTGKDNL LNAWRTPYGA SIFQSKESSS
VLSCDISADD KYIVTGSGDK KATVYEVIY
//
