ID A0A232F6S7_9HYME Unreviewed; 1046 AA.
AC A0A232F6S7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=TSAR_005653 {ECO:0000313|EMBL:OXU26541.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU26541.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU26541.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU26541.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU26541.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU26541.1}.
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DR EMBL; NNAY01000781; OXU26541.1; -; Genomic_DNA.
DR STRING; 543379.A0A232F6S7; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF47; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT DOMAIN 116..393
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 460..978
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 35..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 406..434
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 117571 MW; 1163015B23FDFA93 CRC64;
MAQTLWCRSA GRRRHVRGSG SRSTXQPDEA KTLQELDIDD LESHRSDDPR GMRRHKAAHP
TVQIGRRKEG GIPHETFKKM YDHSPHEVFV QLDELHGVGE EREWRETARW IKYEEDVEEG
ADRWGRPHVA SLSFHSLLNL RRCLETGVVL LDLEEKDLPG LAYRVVEQMV IEELILPEDR
PVVMRALLLR HRHVHEHDRG FRFGAKRNYA SYTSLQSIWF DDEDATREGA ENNNLNDSKP
KIVASNQALD SNNHTVVDMK EELTFTSSNE DMKKGHNDHI LKRIPSGAEA TVVLVGAVDF
LDQPTIAFVR LAEGILMPAI TEVTIPVRFM FTLLGPRNSD LDYHEIGRSI STLMSNTSFH
MIAYKANERR ELLSAINEFL DDSIVLPPGD WERQALLPFG ELKAKSEAIR KRKAKAIEEK
KKKQQQQIQS ENAAAKKALL AGEDEKKPPD DSDPLRRTRR PFGGLINDIK RRYPYYLSDF
TDGLSSSCLA AAIFMYFAAL CTAITFGGLL SDKTHNVIGI SETLVSCCCT GIIMALFATQ
PLVIIGTTGP LLLFDESLYN FCMANNLDFL TMRLYVGAWM AIIALAIACV EGSVLVRLFT
RFTEEIFTGL ISILYIVETF IKLVNYFKRN PLLPAYCFAS DTSNDNNQTV YQDILHQSPV
NNTEISRLME ASQTAVSSVL GISNNRTDFA LYQDSPFIPA HDKVGLLINQ PNTALMCTIL
CLGTFLGAYY LRIFRNSHYL GRSARRAFGD FGVPISIITF VLIDYLAGVK TEKLLVPEGL
SPTLPGRSWL VSPTKGDVPL WMALACCVPA LLVYILVFME TQISELIIDK KERKLRKGNG
YHMDIVVVCL MNFGCGLIGA PWCCAASVRS LTHVNAVTVM SRTHAPGDKP HIVEVKEQRV
SSLLVAILVG VSVLMAPLLR RVPMSVLLGV FLYMGISSTN GVQLFDRVKL FFMPVKHHGT
ANYVRRVQTY KMHIFTLVQI TCLAVLWTVK STKAALALPF FLILMIPLRA QMTHFFSTAE
LRALDSKNPD NEEDEPDFYE EAPLPG
//
