ID A0A232FA84_9HYME Unreviewed; 1086 AA.
AC A0A232FA84;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Guanine nucleotide exchange factor DBS {ECO:0008006|Google:ProtNLM};
GN ORFNames=TSAR_000067 {ECO:0000313|EMBL:OXU27343.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU27343.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU27343.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU27343.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU27343.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU27343.1}.
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DR EMBL; NNAY01000622; OXU27343.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A232FA84; -.
DR STRING; 543379.A0A232FA84; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11856; SH3_p47phox_like; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF201; LD43457P; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 87..237
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 623..794
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 806..920
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1009..1070
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 598..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1086 AA; 122564 MW; D76503EF55BFE3BE CRC64;
MNFQEDKLAK MAGSPTSIEN QIDSFLEQFK RSASRAMEEH HRRSSIYNAS SISRSRSGNL
DLEVLEAEDV ESMTGEIENG ELAVRDVADL LQPQYAIVTG GKTREGCPII TFPDNGNFHN
LTDLDYQRLM LYLTSVPTLH EADLGFHLIV DRRTDKWNSV KTVLLKISAF FPGLVHVVYV
LRPVGFLQKA ISEVSNKLFR EDFKFRVIVL ANVFELHELI EKDQLTEQLG GELAYCHHTW
IQNRISLEKF SSMTQDVSLA LDSFTRRLAE VEFPNNTIAT TTLLSQQQAE YNELKEEILS
AARHGEALLD SVRQLTGKAT ADRLGNVAAV ERLLVQLEET ERTFDLFWSH HSSRLRHCLA
LRQFEQDFRE LQANLGQHLK TIEEMTEVGE TQSRVDQLLR DTSTFQRICR GDIDRAEEVI
TAGQQLLSGR HQCPAEVVEP KCAELQRVCT ILSQRLERRL HTLTKCRELM EHIDKANTWC
TRGIELLAAQ NSSTPADQAL QELQSLIEAA EEFHHPRSIF EDSIMPETKA LVTQVLQRIE
DVSVMCDKRI MSLKQQLMKP ARPIQTVTPE PAKPLQPAPQ CIRPGRILKK ANTMPRMEMG
PVEGGEISSP ESEPRDGEAL RLKRGHVLTE LVETERIYVA ELGSIIKGYK MEMNNEALAH
LVPAALVGKG DVLFGNLEDI YLFHRDTFLR DLENCISNTE LVALLYSYYC QNIPRSERLR
EQIQSEPQFL VTCQQKLGHK LPLAAYLLKP VQRITKYQLL LKDLLKYSDE QSCCVELQEA
LDCMLVVLKC VNDSMHQTAI TGFGGDLNAQ GELLLQGSFS VWSSSKRERL LRLKPSQRHI
FLYEMAVIFC KHSKPQAHTK ATYHFKRYLK TSQIGLTESV KGDARRFEIW LQGRAEVHTI
QASSIDVKQA WVRQIKNVLM SQLAELKGKQ NTALLGKTGH KYGPLRQTIS WDAQSSLSGS
LRTLSVDSNS MVSHLTDVSQ STENDDVGWS SENSNTDDED AFGDIAGPAP GGRYVALADY
CAMGQSEVTM REGDNLELLK VGCAGWWFVK LIGAGIEGWA PASYLEPISR KTCRSSQSVN
SSQEAM
//
