ID A0A232FBR6_9HYME Unreviewed; 139 AA.
AC A0A232FBR6;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=CDGSH iron-sulfur domain-containing protein 2 homologue {ECO:0000256|RuleBase:RU369084};
GN ORFNames=TSAR_010962 {ECO:0000313|EMBL:OXU28271.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU28271.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU28271.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU28271.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU28271.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|RuleBase:RU369084};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|RuleBase:RU369084};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389, ECO:0000256|RuleBase:RU369084}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004389,
CC ECO:0000256|RuleBase:RU369084}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008624, ECO:0000256|RuleBase:RU369084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU28271.1}.
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DR EMBL; NNAY01000456; OXU28271.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A232FBR6; -.
DR STRING; 543379.A0A232FBR6; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010506; P:regulation of autophagy; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.5.90; CDGSH iron-sulfur domain, mitoNEET-type; 1.
DR InterPro; IPR045131; CISD1/2.
DR InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR InterPro; IPR042216; MitoNEET_CISD.
DR PANTHER; PTHR13680; CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13680:SF5; CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF10660; MitoNEET_N; 1.
DR Pfam; PF09360; zf-CDGSH; 1.
DR SMART; SM00704; ZnF_CDGSH; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714, ECO:0000256|RuleBase:RU369084};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU369084};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU369084};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU369084};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU369084};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 87..125
FT /note="Iron-binding zinc finger CDGSH type"
FT /evidence="ECO:0000259|SMART:SM00704"
SQ SEQUENCE 139 AA; 15341 MW; A8217806CCAA029C CRC64;
MEPIAHLVKV SVPNYLAGLP IPDSIGGWFR LGAFSLSSVA VRDWFSLIPP TAALVGLGYM
SYRAFCPKAR PAPTGQVNHK IKKDCNKVVD SVDVEDITEK VAFCRCWRSE NWPYCDGAHG
RHNNECGDNL GPLVINKKQ
//
