ID A0A232FE93_9HYME Unreviewed; 5302 AA.
AC A0A232FE93;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 13-SEP-2023, entry version 21.
DE RecName: Full=UBR-type domain-containing protein {ECO:0000259|PROSITE:PS51157};
GN ORFNames=TSAR_002359 {ECO:0000313|EMBL:OXU28982.1};
OS Trichomalopsis sarcophagae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Pteromalidae; Pteromalinae; Trichomalopsis.
OX NCBI_TaxID=543379 {ECO:0000313|EMBL:OXU28982.1, ECO:0000313|Proteomes:UP000215335};
RN [1] {ECO:0000313|EMBL:OXU28982.1, ECO:0000313|Proteomes:UP000215335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Alberta {ECO:0000313|EMBL:OXU28982.1,
RC ECO:0000313|Proteomes:UP000215335};
RC TISSUE=Whole body {ECO:0000313|EMBL:OXU28982.1};
RX PubMed=28648823; DOI=10.1016/j.cub.2017.05.032;
RA Martinson E.O., Mrinalini, Kelkar Y.D., Chang C.H., Werren J.H.;
RT "The Evolution of Venom by Co-option of Single-Copy Genes.";
RL Curr. Biol. 27:2007-2013(2017).
CC -!- SIMILARITY: Belongs to the UBR4 family.
CC {ECO:0000256|ARBA:ARBA00009970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXU28982.1}.
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DR EMBL; NNAY01000352; OXU28982.1; -; Genomic_DNA.
DR STRING; 543379.A0A232FE93; -.
DR Proteomes; UP000215335; Unassembled WGS sequence.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19680; UBR-box_UBR4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045841; E3_UBR4_N.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR047509; UBR4-like_UBR-box.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF19423; E3_UBR4_N; 2.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000215335};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1750..1823
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 1750..1823
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 145..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1517..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1821..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2251..2270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2536..2569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2983..3110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2548..2569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2983..3039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3067..3105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5302 AA; 588764 MW; F132C8880F04C007 CRC64;
MAAKSGGVVD WSSIIKPIFA AYYGSFNKTD IIELVKAVIQ SEAELVSHEE EYEAFYTSFA
ALAADYIDSK SQIPIVWQAC RILLTYLVGK LPQPSSQTGE SSASTILTTR QLLLPIRALC
VGQSLLAKSE EVVLITILKN AKLPQSVKSS PTSGEKEGTP QPIKETKRAR SDLSTSILEQ
LTMPLQDFAI SNDIALDTAN KSNSEATNTE QGADTKMMFT ANNINTLQSM GAGDMLLNMC
SNLPHLSRYA RKYQAYLNRK SFCLPANQSE AQSIRHSLHS VVNDINIVHS VVSLPILEPL
TPAKLEKLSL LTMSCLYCSI ANATASSIVG ITNAISPKCS SNTSANPQSS QSTKSTEEEY
DALAITVVER SLEIFTLVSN IIRHSTRAGG HILQNHLLIG VWLLVAGLQA QLSVSSFSVT
DKGKEEKGKS PSKARDGSGR INLMKVLASR RKCDIKYYIF LSLAKYRQQG FGVLSVALAS
HALTLMGALL EDVSVEAGIE QVPPPEPAPL DILATATALE RVSTFFQAAP LNHLLFYLAT
ISYRKACTLK RVQKHPLEGD TLSQSDSTTY YEDLYSCSES STDQEEDSEP ILGLWFEETL
DSSDGPPANA SKESNEETNT ERNATVVPDN REPHGYISLA TQIFQFMNQH LIGSRSAYVR
EYVVNGLVEQ QMVILAAIIR DLDHEAARTE TGTISVFYGA TLGAMYSEFS QALSRYTHNL
LARNTLSETL QNTLLHHLGV SPWSTENASP STWPLQVYPR TLSVLAQILL LKPQSEKEAA
CISIWQRLVT TMVENVCNPP TTFETENEDL NVEHAQLVLF LFHSLNLMQK KSVLLVTGSG
AVRCSEAIKS PMKDSQILHL SRLLLLLEYM MKHLYDAPST LLEQVQWNLF SATSLVSDTK
EGNKQASRIY TPWKEIEDNY RKFGPQDEFS MKPRFYNLTA YDFNNQDTPK LDGLACNFIL
GTPDKMKYPL LVDALIDILN ILNQTSLPRK TGPDGKDKMT FTGLCAIQYC FSICWRLLLM
LPPSTPYMDK LALGEEIPAG PLLLHSLIWG PRAAYKTFTG WMKDCLVKQG MYTQYAENLL
KTVSSTVNSL KYDVALAKNC IKSLKPEVSA TEKIVPKASL PKLSSLCILS AVVGKLQVLM
DESIYKSGND NIEASKVQQP AESTSSNVNK LVVDILPHIL SLTDAMLASC RSSILYQIQE
TSESSKKYTM RDFVVLDEVI CMSGASWASE ASLISLLPNN VRSVLDKWKA ISIAHVPWNT
YANDIIPAES YILATINHHI SSLSEYGSFS INPSLKNLLY SLVSFIMEYV NSITAQENTD
ARIHRHATDI LISLTMDVRM EYFHEMASKT LNTLIGEPDS ETRQIREHLF VLNHTYNLIV
DYTSNLEDTI NISIDGKILK QCIKYWEQLL EKPVGCKALD QFFAPSTNRT LVSVLLSIAS
PQSSQQFSNH VLHFFNRLFK TVSEKDSDGS LDRLCRSVAN LAKVENEKLQ SWLAHVILGS
ASLSPSASTA VLPAPASSAA PATTTSTTPA AVPEDAPKND VPNNATNNEQ TQGPWQLTSL
LTETTTPNNQ TTISNDEQQS LQENNQLLRA LTNYIVKENS NISDGVSVTI LQALIPIAYR
ILSTTPEGVS FSELMQVMST LADAGSDKGH ILLFQSATEW LELCKQQFLS KDPNLDKSSS
YIEAGCCILN YVADIVNAVC PQKLLIGQDR ATSPPWEGAQ PTNDVNDSDW IDEIAHDEED
SGAEDSDEDS LCNKLCTFTI TQKEFMNQHW YHCHTCNMVD GVGVCSVCAR VCHRGHDVTY
AKYGNFFCDC GAKEDASCQA LTKRSPQSSE HPTNNGASYH ASSGTADNHM MLTSSLRRRA
SSPVHFNEKH ERTSKDKQKQ LALAKQLEGS KEWVLSKLWG SGLVSSLVRL TRALIPAVEM
SCEKFSPVGC HSRAQAALSQ LHYVEKKFEH TDQLMLPTLG SQEGAFENVR MNYSGDQGQT
IRQLLSAHMI RRVAMCCLSS PHGKRQHLAV SHEKGKITVL QLSALLKQAD SSKRKLTLTR
LASAPIPFTV LSMTGNQWNE DFLAVCGLKD CHVLTFNSTG TVSDHLVLHP HLETGNFIIK
AIWLPGSQTQ LALVTADFVK IYDLSKDALS PQYFFLVPTG KIRDCTFIHT ENNEFHLLLM
SSAGYIYSQA MDEESLAKHG PFYVTHTLEV YHSDIKDNGQ VCGGGVSIYY SHALQLLFFS
YVSGKSFVAR MKYVDDIDLV NLINITNKSN GSSGGSGSGN KSNNNQPQPL CQWSEVANHP
GLVCSVLQTS NNPVILMIKP TTIMIQEIKV VPAKAKIMDM VAIRHPSSNA EHRTTLILLC
EDGSLRIYMA AMEQTGFWMS SSVQPVGLIS TLKQTKKKKA LKAGKPSGSV NFPIDFFEQC
QAMNDVEFGG NDLLQVYNVV QIKHRLNTTG MYVVSTKTMG FNVEVTNNDA TLVMTGIRVQ
LGSQDVQRAP MYIEVFGRSI RTTLTRSRWF DIPLTREESL QADKKLTITF GPSQDPEGVI
MVDSIKIYGK TKDAFGWPEE PEDIPAGQST PAQATAGTTT GNDADNPTIS PTPLSSVDKM
ISSILEVLES SFTLSNDESK APLKQTAIEV ASTLLTLPTP PPVQVHTTAL LAALHNARSV
YHSHKDQVLL NHVLDSLKAM RETEDPCDID AENFYRLVVI VRSIAVTRPQ NLYKFAEQHC
TKTSEEIHIP ILEQDRPTPQ ASTSENNNPH LMLQLMNVLW LLHAAYPKNL ALAPVVVPGL
THTEAVIHAI IEIIHAFTIC DVDGFTPLAA KLYLQLLLSS DTTVSFNAKQ AIIKVLRPRY
KKRRVYIPSP PNYTASNATA QVEEKATPIV PQPQPPPEPV EADEQFDVDN VVSMVLLGGE
GSNQAGAAAA RAVNPLEALL GPGGFPQLLD MPQAEDDEAM VELAIALSLQ DHEGGAPMQA
LQQGLQQSLA NLQGLEAHLS GQALQSLQAL AAQGLGQAQG AAQAQEAGHY SDTTASAGGS
DDEGSTAATD GSTLRTSPAE QGGSGGSKGS ESGGSESGGS AVDSIMGEHS VSGRSSAYGD
GQADGMSAAG SRSNQQARSE SSSINAPATF AGTSQEGTTE QEQGIEPESD VAGEITTNLH
DVRLMLLDKL MQFIPNLSNV PGVRAIPFMQ VILMLTSDLD GQDERDKTCF TNLLNLFVKE
LNMETPDVAD ICARTNKREV HLVIMRLLSV LMSRSKYNTK SQSESSNFTS QMTAAILSKS
GVIDYCLNLL KALLEYWKTV STDDSGAVIG GQLLKEHLTT SPPDMSPFFL RQYVKGHAND
VFEPYPQLLT EMALRLPYQV HKYAESNTIQ PAFDQQSWYF YLCEYMMSYQ TPFVRRQVRK
LLLFICGNKD KYRQLRDLHA LVSHVKSVQQ CCNTGGYDVL EPIPHSINLP YDSLVELIEH
LKCCVEIATS RTGNWQRFCL KHNTVLSYLF TISTLLDEGV SPTVLQLLQC AICGSSKLKD
IKGKEFKSAI NTKERRDREK SEDSDTEAKF EETQCITLVE QIQKQVSPAL LIKFIQTFLL
ETNNTNIRWQ GHSLALAIYK NSSAADQEGL LDHLWRLWPL LPMYGRKAAQ FVDLIGYFSL
RTPQTGKKMY SYMEQAVAVL HAQNQLLSRH PNANLYANLA QFVELDGYYL ESEPCLVCNN
PEVPMSTIKL SSIKVDSKFT TTTQIIKLVG SHTISRITLR IGDLKRTKMV RSINVFYNNR
TVQAVVELKN KPAMWHKAKK VTLVQGQTEV KMEFPLPIVA CNLMIEYSDF YENIQASSET
LQCPRCSASV PANPGVCANC GENVFQCHKC RAINYDEKDP FLCHACGFCK YAKFDYTLTG
RPCCAVDPIE SDEDRKKTVV TINTLLEKAD RVYKTLIANK PTLEMLLVKI SEHRLDRSLD
DGVTTQTTTG STQVNRAIQL LAQKYCGECK ISFEELSKII QRVLACRREL VAYDRNQRGQ
GTIQYQRASC VSDCTEKNTS PANPPVGRCY GCASSATEHC LTLLRALATN SAAREVLCKQ
GLIQELVEHN LRRGTIQVQE EVRQLLCLVT RDNAQSTKEL CSLLTNRVTM TLRGRVVTSD
LSTAVRHEMA LLGALIQKED TCWEQKLRCV MQLFLMACKD SKSPVVMESI ILPCLKILQS
LLKPEQPISK KNKDKTIDSL ATVQPPDGVS IDLAKWLDGD SKYSYAEWLQ RMPGKKSDSH
QNKPLKKEEA RILYLSEKYG HRWYYRCMRL RGIQPLKLAN GSWLKEVIFN PSSRLARQVV
CNMVENLCQG TDRKKEVLLL LTGYLDELCV AGESSAEYLA LYQNLIRQAP WKQFLAVRGV
LNILADLLTK EIAELHRLEE TTLTSDLAQG YSLKMLTELL ATFLEQENIK QQYKGRLVGA
VLNGYLSLRR LVVQRTRLID ETQEKLLELL EEMTTGTEEE TKAFMAVCVE TVQKYSPQDI
RTPVFIFERL CSIIYPEEND VGEFFLTLEK DPQQEDFLQG RMLGNPYSSL EPGLGPLMRD
VKNKICQDCE LVALLEDDNG MELLVNNKII SLDLPVKEVY KKIWVLEGGE CDAMRVVYRM
RGLLGDATEE FVETLNVNSE QEVNNEEVYK MANVLADCGG LQVMIERLAS IQDVNRAKPL
LQVLLKLFRL SVKVKKNQEV LSQPELGAVT VLLDVLQRVI ATDSDNSQSK VTEQLLDIME
TILSNAASQP LETFEEFSRT LGSPEHVKAL LSCTQSTAVR TSANVLLHLA RVLAALTYGN
KEKMELLCDY FKPVLNFYKF DFEHTPEDEQ KLELFCVLTQ GIERNAIGNT LKDHIISMNI
VKDAFEYITV HAPCVKPTLL RTDSDELKDF ISKPALKYIL RFLTGLATDH EPTQLAASQF
TISIIHRLEQ VSSNEHVGSL AENLLEALCT NKKVAELIEE ARQHTRSEKK RLAMAMRERQ
LGALGMRTND KGQVTASGTI LQQMEDLGDE TGLVCVICRE GYKFKPNMVL GVYTFTKRCN
VEEFETKQRK TVGYTTVSHF NVVHVDCHMS AVRLARARDE WESAALQNAN TKCNGLLPLW
GPQVPESAFA SCLARHNTYL QECTGHRDIS YSSTVHDLKL LLLRFAQEKS FHDDTGGGGP
QSNMHMIPYL IHMALYVINT TRSASREDKA LVTYLESNAS SPWLDSCYEA EGPLYQCTLS
ILILTPARWN KNKLTHLRRL ILLAHQRYVS PSATTKTLLD TSVKDYSVYK SVLIFFGLID
NIYAHFFKKV NVLTDDQWPA VLAEYIRHND EALLKASEKI LAAYRDELLP CASFDEFCDV
AGLLEEISNP STFISDLMQS LA
//
