GenomeNet

Database: UniProt
Entry: A0A233HMF8_9VIBR
LinkDB: A0A233HMF8_9VIBR
Original site: A0A233HMF8_9VIBR 
ID   A0A233HMF8_9VIBR        Unreviewed;      3967 AA.
AC   A0A233HMF8;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:OXX62712.1};
GN   ORFNames=B9J89_08350 {ECO:0000313|EMBL:OXX62712.1};
OS   Vibrio sp. V15_P4S5T153.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=1938669 {ECO:0000313|EMBL:OXX62712.1, ECO:0000313|Proteomes:UP000215241};
RN   [1] {ECO:0000313|EMBL:OXX62712.1, ECO:0000313|Proteomes:UP000215241}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=V15_P4S5T153 {ECO:0000313|EMBL:OXX62712.1,
RC   ECO:0000313|Proteomes:UP000215241};
RA   Vazquez-Rosas-Landa M.;
RT   "High clonality and local adaptation shapes Vibrionaceae linages within an
RT   endangered oasis.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC       family. {ECO:0000256|ARBA:ARBA00029443}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OXX62712.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NDIJ01000013; OXX62712.1; -; Genomic_DNA.
DR   Proteomes; UP000215241; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd12114; A_NRPS_TlmIV_like; 1.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd19535; Cyc_NRPS; 1.
DR   CDD; cd05274; KR_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 3.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 3.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   3: Inferred from homology;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          11..434
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1593..1668
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2520..2594
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3594..3669
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3967 AA;  442777 MW;  9F6C2C08C0AA5B8C CRC64;
     MNTLDPCFGN SDPIAVIGLA CRFPKAPNAE QFWHNLVNGI SGQSYFSEQE LQTAGITTSL
     SAQENFVPSG AIIDNPDYFD ASLFGYSPTE ALSIDPQQRL FLQIVWHALE DAGYAPNAIQ
     SKTGVFGSIR TSTYPSFADF DVTQVGQVKG LQALLGNDKD YLATRVAHKF NLTGPAFTVQ
     TACSSSLVAC HLACESLRSG ECDMAIAGGV AVSFPQSSGY LYQPGMIFSP DGLCRPFDID
     ANGTFGGHGL GCVVLKRWED ARRDGDTILA LLRGSAINND GQDKVGFTAP SVRGQAQVLS
     DALHLADVLP DEVEMIEAHG TGTKLGDPIE VRAIKQAYQR SIEAKPCFLG SVKSGFGHLD
     TAAGIASLIK TVLSVSRRKI PASLNVSQAN PALELTGSGF QLATTTIDWL NETRTAAVSS
     FGIGGTNCHM IVQSAPELAD TTPLNPRSEN AKLLISANSE TSLRKLAGEY ATRLEQPTHH
     SDIAYSAMLK RALDLPYRLA IDCNSAAIQA LRDFALTGQA GRDLHVGQPS ATGKVVWCFT
     GQGSQWANMG QELYHRSAAF RDSIELSQQY ALGSLEIRLT DALFGHRTEL LQRTDYAQLA
     IVAFEIAMAA HWQSKGFRPD MVMGHSVGEF AACVVSGYLT HQQAIALVSE RGRLMHLCAQ
     RQAGSMLAIF AKPNTLETIP ALRELDLAAH NGAQHWVYSG HQRDVDNAIL ELDKHAIRYK
     KLDVSCAAHS RLLDEILASF HEFAAPITAK QGTIPLISSV TGQVADNAAS FNAEYWTRHV
     RDTVQFQRAI ESALAKQAKL LVEMGPSAHL TAMGQRETWS TDCVWLGTSH PSIPTQRLET
     ELLAALFVAG CNNKWSALFA LQGRPCRLPL YVFDEQRYWY PTSDVKTIET ALPKQTLSVP
     PPTTIAALYP MLRCCVIRDL IHSCTAQPRF TLRDLIRGGR LLPKHRDLIT TLLNSLLEHG
     YLQQGHQCYQ FTAVSLPTTD VVAQWLRDAL ATNQEPATVQ LSDIRALCET PARLKQVLRC
     YHTSPLQLKK QVAEIKQRLL SPLTPSIQPN LAIPFSNQTQ LFYVDWVMTP TETDWHQLIT
     LHMPSFVQEE RSDWLIVAAP SLDPKTITQL VVHRTTQLWG QVQYQLRGCL TSGEWAWIGQ
     IQTPNFDDSQ PHSLLPSPHQ RYEWQWLPVA ASQARLNVSE SDLQQALQCQ GEIYRVNETV
     SLFVLPDGEL VECAEKVIQS LSADFTTLYV LTSQAMATDA TQSVAAEKVA LMSLLRVARA
     EHKQQGIYLL DIEPSVENHH HQALILSQAL NSAPFHLATE IAYRNHSYWI PQLVHAKTVP
     DLIPSSWFTT SGWHLVTGGM GGIGRHIIKW LAQSGARHIA VIGRREPSDW PEFCQTIARF
     GCQVMTLLCD VSQEGELQRM LNDWPRTLPI IGAFHAAGTS LTGLINQWDP QQSALLIQTK
     CHAFVALHQW LEAQEAQYLL GLSSAASLGA VGQGAYALAN AFLDGYALAQ QGSSRCRMMS
     IGWGAWDSIG MTADSALLDT LAKEGMHTLN VQEGLWQISQ SLLSSAPFVL AMNIEPQHAN
     FQPYLDPLNT AIDTVDTIDC LVSPKPLTRP TVSDVGQWLT ERLRYQLGMS DDTPIRVDQD
     LLQLGLDSLQ FLELSAVIQK QFAVKIDAEQ AYQNLTISGL VEAIARVPAA PESDSMLTHF
     VNDPHNRYTP FPLTPIQHAY WIGREPWVQY GGIACHVVFE WDKDLTEFNP QQFAAAWNAL
     IKRHDMLRMT VNHAGEQVVH AEVDYFPIVE RDLRSLSEEA QHVELEQIRQ QMRHQVRAAD
     VWPLFDVQLS RLSEHKVRLH LNLDLLQFDV QSFKIMMDDL ATAYQGKDLE PLSITFRDYV
     MHEQTLRHSA EWQNSWHYWQ QTIPTLPKAP QLPLNPDYQH HAPEFITLEG RLSDSEWQTL
     KSVWQQWGVT PSAGLLTLFA HTLANWTASP DFTLNMTFFN RQPFHEAVQD LIGDFTSVLL
     MDFQHDSSTD LKQRILQTQS KLWQRLGHSQ VNGVEVIREL AKHWKSSGQL SEQEAALPLT
     PVVFTSMLGM SMDGMDIEQA MTHLLGDPVY VLSQTPQVWL DHQIMEIEGN LAFNWYCMAG
     VLAPDLLENL FNQYLSLLQQ CAADPQFFER SLTQPEPLHP LLPPDHVIAE STLDWHNMSL
     PEISPQIVQE VTQAWAQLEH RALRGIWTTL RNHQLFTSPE QAYRAPQIIQ QLKVTDKHHK
     LIQLWLDQLC REGVLTEKDG EYRFQDDFPK APRLPLPQQA WCQRLDTYLE DCLKQHPALL
     NGRHSALELL FSDPAITDSL YRCNPSLQIL NLSAARAIYA LGQQQAQGLN ILEVGAGTAA
     TTREVLSLAS STIRHYQFTD VSRLFLHEAR ELLSEYPQVS YGLFDINQPI DEALKMDGGY
     QVILAVNVLH DAIDLAKCLQ GLRALLADDG YLILIEATDQ HSPMQLATVG FIEGINAFND
     FRQSTGSGML TQPAWLTLLA EQGLEPQLSY PNSEVSALRQ HLIVTQKRPQ HSPQTLGQSE
     SYQQQIEQIK SIWQTFLHGE INHDTDFFLA GGDSLMATKM IVALQHAGIK QASLQSLFEH
     PKFQDFCCQF ESAPSTATTT VETDIIEPNT TLESQDNTTQ QKNGVCVRHY PLTPLQNAYW
     LGENALFSLG NGVAHFYAEL EIKHLDRLRL TQAWNRLVQL HDQLRGEIDA GQYHIHRQVP
     EYQPQFLDLS SWDEPQKTRW IDEARTQIAA HGVATHQWPL FDISILQVDG ETSLVHLVLD
     LVVADGKSLN TLFQQWFALY DDLSIELALP TMSIDNYLLE LEQLKQSEPY QQAQAYWLDR
     VPTLPEAPAL PLADKRSEHL AQSVLTHHLS AEQWSQIQAV SFAHNLLPSM SMLSTFCLVI
     SHWSAQKHFA INILHSNRPA MLPQSADVIG NLSTTSMLEV RTQPGSLLAF VEQIQQQMAD
     DMAHSLFDGQ SVLTEKNRHN HNLNAGMPVV FNDTLSVGQH RPLPYGKLNA FGAQTPHVYL
     DSMLIPSPCG GVIIKWTIQE NYLKSGVFEA MFAAYTHTLE TLTSRDWQQP LALALPSAQQ
     QKRDQVNATQ GEVKLVLDNQ TTACVATLCD LVRLGVEQHP QRIAIEQGEL ELTYQTLWFS
     AQHLAAQLIE QQDDAPLVAV VMNKGWQQVV AVLAILLAGK AYMPIDGAYP EPRIQALLKQ
     GAVSTIISDS SEPCRTDDYR VLFPALMTEA KAHFIPVANQ PTDLAYVIFT SGSTGQPKGV
     MMEHGAVVNT LLDINQRIAL DHRDRVLAIS SLNFDLSVFD IFSTLSCGAR LVIPQTSPSQ
     DPEALVHLAQ QSAITVWNSV PAFAQLLVDL LENRSNPLPH LRQIMMSGDW IPVNLPDRLN
     TLTPQAKLLS LGGATEAAIW SICYPIEKSY TTHSSIPYGK PLTHQQFYVL DEQLNPCADW
     VTGELYIGGR GLARGYWHDQ EKTDFAFIEH PTLGQRLYKT GDLGRYLPDG NIEFLGRNDH
     QVKINGYRIE LGEVENALRQ CALNASGIDI LDAIVQPDRT AQNGARLVAY IQYAPHSRRD
     NQALLDHARR LLPQYLCPSQ IITLEHLPLT ANGKVDRSAL PRPDAHIAAD QLRMPHSQQE
     QLLAQIWSEC LNFAPIPANQ SFFDLGGNSL IAVRLLNQIN HRLNLALSAG QLQTHDTVER
     LATLLTEQTQ PLHHAPVKLS SNGSNRTSTL FIVHPIGGHL LSYQALAKEL SQITLYGLAY
     PDRHDKSAPK TDIVALAAHY LSMIRHVQPT GPYQLAGWSF GGVVAFEMAR QLMEQGEEVS
     HCILIDSYKP SQNPNQRLTE ASIRQYFYAD CIGRFPALKE HVISNFESET QFCAELAKAF
     LETGSGLLDS ASLAELLAIY QQNLRAMLDY QPPYLETLPV TLYSAQNHSQ LDFMRYQHPE
     MAKRRCHGWS DCCHPIIHRM QGDHYTLLQQ PHVKTLAHEI STLLGHRSHS LNSFHQQNVK
     ELENEES
//
DBGET integrated database retrieval system