ID A0A233HMF8_9VIBR Unreviewed; 3967 AA.
AC A0A233HMF8;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:OXX62712.1};
GN ORFNames=B9J89_08350 {ECO:0000313|EMBL:OXX62712.1};
OS Vibrio sp. V15_P4S5T153.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1938669 {ECO:0000313|EMBL:OXX62712.1, ECO:0000313|Proteomes:UP000215241};
RN [1] {ECO:0000313|EMBL:OXX62712.1, ECO:0000313|Proteomes:UP000215241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V15_P4S5T153 {ECO:0000313|EMBL:OXX62712.1,
RC ECO:0000313|Proteomes:UP000215241};
RA Vazquez-Rosas-Landa M.;
RT "High clonality and local adaptation shapes Vibrionaceae linages within an
RT endangered oasis.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OXX62712.1}.
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DR EMBL; NDIJ01000013; OXX62712.1; -; Genomic_DNA.
DR Proteomes; UP000215241; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd12114; A_NRPS_TlmIV_like; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19535; Cyc_NRPS; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..434
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1593..1668
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2520..2594
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3594..3669
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3967 AA; 442777 MW; 9F6C2C08C0AA5B8C CRC64;
MNTLDPCFGN SDPIAVIGLA CRFPKAPNAE QFWHNLVNGI SGQSYFSEQE LQTAGITTSL
SAQENFVPSG AIIDNPDYFD ASLFGYSPTE ALSIDPQQRL FLQIVWHALE DAGYAPNAIQ
SKTGVFGSIR TSTYPSFADF DVTQVGQVKG LQALLGNDKD YLATRVAHKF NLTGPAFTVQ
TACSSSLVAC HLACESLRSG ECDMAIAGGV AVSFPQSSGY LYQPGMIFSP DGLCRPFDID
ANGTFGGHGL GCVVLKRWED ARRDGDTILA LLRGSAINND GQDKVGFTAP SVRGQAQVLS
DALHLADVLP DEVEMIEAHG TGTKLGDPIE VRAIKQAYQR SIEAKPCFLG SVKSGFGHLD
TAAGIASLIK TVLSVSRRKI PASLNVSQAN PALELTGSGF QLATTTIDWL NETRTAAVSS
FGIGGTNCHM IVQSAPELAD TTPLNPRSEN AKLLISANSE TSLRKLAGEY ATRLEQPTHH
SDIAYSAMLK RALDLPYRLA IDCNSAAIQA LRDFALTGQA GRDLHVGQPS ATGKVVWCFT
GQGSQWANMG QELYHRSAAF RDSIELSQQY ALGSLEIRLT DALFGHRTEL LQRTDYAQLA
IVAFEIAMAA HWQSKGFRPD MVMGHSVGEF AACVVSGYLT HQQAIALVSE RGRLMHLCAQ
RQAGSMLAIF AKPNTLETIP ALRELDLAAH NGAQHWVYSG HQRDVDNAIL ELDKHAIRYK
KLDVSCAAHS RLLDEILASF HEFAAPITAK QGTIPLISSV TGQVADNAAS FNAEYWTRHV
RDTVQFQRAI ESALAKQAKL LVEMGPSAHL TAMGQRETWS TDCVWLGTSH PSIPTQRLET
ELLAALFVAG CNNKWSALFA LQGRPCRLPL YVFDEQRYWY PTSDVKTIET ALPKQTLSVP
PPTTIAALYP MLRCCVIRDL IHSCTAQPRF TLRDLIRGGR LLPKHRDLIT TLLNSLLEHG
YLQQGHQCYQ FTAVSLPTTD VVAQWLRDAL ATNQEPATVQ LSDIRALCET PARLKQVLRC
YHTSPLQLKK QVAEIKQRLL SPLTPSIQPN LAIPFSNQTQ LFYVDWVMTP TETDWHQLIT
LHMPSFVQEE RSDWLIVAAP SLDPKTITQL VVHRTTQLWG QVQYQLRGCL TSGEWAWIGQ
IQTPNFDDSQ PHSLLPSPHQ RYEWQWLPVA ASQARLNVSE SDLQQALQCQ GEIYRVNETV
SLFVLPDGEL VECAEKVIQS LSADFTTLYV LTSQAMATDA TQSVAAEKVA LMSLLRVARA
EHKQQGIYLL DIEPSVENHH HQALILSQAL NSAPFHLATE IAYRNHSYWI PQLVHAKTVP
DLIPSSWFTT SGWHLVTGGM GGIGRHIIKW LAQSGARHIA VIGRREPSDW PEFCQTIARF
GCQVMTLLCD VSQEGELQRM LNDWPRTLPI IGAFHAAGTS LTGLINQWDP QQSALLIQTK
CHAFVALHQW LEAQEAQYLL GLSSAASLGA VGQGAYALAN AFLDGYALAQ QGSSRCRMMS
IGWGAWDSIG MTADSALLDT LAKEGMHTLN VQEGLWQISQ SLLSSAPFVL AMNIEPQHAN
FQPYLDPLNT AIDTVDTIDC LVSPKPLTRP TVSDVGQWLT ERLRYQLGMS DDTPIRVDQD
LLQLGLDSLQ FLELSAVIQK QFAVKIDAEQ AYQNLTISGL VEAIARVPAA PESDSMLTHF
VNDPHNRYTP FPLTPIQHAY WIGREPWVQY GGIACHVVFE WDKDLTEFNP QQFAAAWNAL
IKRHDMLRMT VNHAGEQVVH AEVDYFPIVE RDLRSLSEEA QHVELEQIRQ QMRHQVRAAD
VWPLFDVQLS RLSEHKVRLH LNLDLLQFDV QSFKIMMDDL ATAYQGKDLE PLSITFRDYV
MHEQTLRHSA EWQNSWHYWQ QTIPTLPKAP QLPLNPDYQH HAPEFITLEG RLSDSEWQTL
KSVWQQWGVT PSAGLLTLFA HTLANWTASP DFTLNMTFFN RQPFHEAVQD LIGDFTSVLL
MDFQHDSSTD LKQRILQTQS KLWQRLGHSQ VNGVEVIREL AKHWKSSGQL SEQEAALPLT
PVVFTSMLGM SMDGMDIEQA MTHLLGDPVY VLSQTPQVWL DHQIMEIEGN LAFNWYCMAG
VLAPDLLENL FNQYLSLLQQ CAADPQFFER SLTQPEPLHP LLPPDHVIAE STLDWHNMSL
PEISPQIVQE VTQAWAQLEH RALRGIWTTL RNHQLFTSPE QAYRAPQIIQ QLKVTDKHHK
LIQLWLDQLC REGVLTEKDG EYRFQDDFPK APRLPLPQQA WCQRLDTYLE DCLKQHPALL
NGRHSALELL FSDPAITDSL YRCNPSLQIL NLSAARAIYA LGQQQAQGLN ILEVGAGTAA
TTREVLSLAS STIRHYQFTD VSRLFLHEAR ELLSEYPQVS YGLFDINQPI DEALKMDGGY
QVILAVNVLH DAIDLAKCLQ GLRALLADDG YLILIEATDQ HSPMQLATVG FIEGINAFND
FRQSTGSGML TQPAWLTLLA EQGLEPQLSY PNSEVSALRQ HLIVTQKRPQ HSPQTLGQSE
SYQQQIEQIK SIWQTFLHGE INHDTDFFLA GGDSLMATKM IVALQHAGIK QASLQSLFEH
PKFQDFCCQF ESAPSTATTT VETDIIEPNT TLESQDNTTQ QKNGVCVRHY PLTPLQNAYW
LGENALFSLG NGVAHFYAEL EIKHLDRLRL TQAWNRLVQL HDQLRGEIDA GQYHIHRQVP
EYQPQFLDLS SWDEPQKTRW IDEARTQIAA HGVATHQWPL FDISILQVDG ETSLVHLVLD
LVVADGKSLN TLFQQWFALY DDLSIELALP TMSIDNYLLE LEQLKQSEPY QQAQAYWLDR
VPTLPEAPAL PLADKRSEHL AQSVLTHHLS AEQWSQIQAV SFAHNLLPSM SMLSTFCLVI
SHWSAQKHFA INILHSNRPA MLPQSADVIG NLSTTSMLEV RTQPGSLLAF VEQIQQQMAD
DMAHSLFDGQ SVLTEKNRHN HNLNAGMPVV FNDTLSVGQH RPLPYGKLNA FGAQTPHVYL
DSMLIPSPCG GVIIKWTIQE NYLKSGVFEA MFAAYTHTLE TLTSRDWQQP LALALPSAQQ
QKRDQVNATQ GEVKLVLDNQ TTACVATLCD LVRLGVEQHP QRIAIEQGEL ELTYQTLWFS
AQHLAAQLIE QQDDAPLVAV VMNKGWQQVV AVLAILLAGK AYMPIDGAYP EPRIQALLKQ
GAVSTIISDS SEPCRTDDYR VLFPALMTEA KAHFIPVANQ PTDLAYVIFT SGSTGQPKGV
MMEHGAVVNT LLDINQRIAL DHRDRVLAIS SLNFDLSVFD IFSTLSCGAR LVIPQTSPSQ
DPEALVHLAQ QSAITVWNSV PAFAQLLVDL LENRSNPLPH LRQIMMSGDW IPVNLPDRLN
TLTPQAKLLS LGGATEAAIW SICYPIEKSY TTHSSIPYGK PLTHQQFYVL DEQLNPCADW
VTGELYIGGR GLARGYWHDQ EKTDFAFIEH PTLGQRLYKT GDLGRYLPDG NIEFLGRNDH
QVKINGYRIE LGEVENALRQ CALNASGIDI LDAIVQPDRT AQNGARLVAY IQYAPHSRRD
NQALLDHARR LLPQYLCPSQ IITLEHLPLT ANGKVDRSAL PRPDAHIAAD QLRMPHSQQE
QLLAQIWSEC LNFAPIPANQ SFFDLGGNSL IAVRLLNQIN HRLNLALSAG QLQTHDTVER
LATLLTEQTQ PLHHAPVKLS SNGSNRTSTL FIVHPIGGHL LSYQALAKEL SQITLYGLAY
PDRHDKSAPK TDIVALAAHY LSMIRHVQPT GPYQLAGWSF GGVVAFEMAR QLMEQGEEVS
HCILIDSYKP SQNPNQRLTE ASIRQYFYAD CIGRFPALKE HVISNFESET QFCAELAKAF
LETGSGLLDS ASLAELLAIY QQNLRAMLDY QPPYLETLPV TLYSAQNHSQ LDFMRYQHPE
MAKRRCHGWS DCCHPIIHRM QGDHYTLLQQ PHVKTLAHEI STLLGHRSHS LNSFHQQNVK
ELENEES
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