ID   A0A235G6R7_9NOCA        Unreviewed;       259 AA.
AC   A0A235G6R7;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Steroid 5-alpha reductase family enzyme {ECO:0000313|EMBL:OYD69279.1};
GN   ORFNames=BDB13_2842 {ECO:0000313|EMBL:OYD69279.1};
OS   Rhodococcus sp. OK302.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=1882769 {ECO:0000313|EMBL:OYD69279.1, ECO:0000313|Proteomes:UP000215121};
RN   [1] {ECO:0000313|EMBL:OYD69279.1, ECO:0000313|Proteomes:UP000215121}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OK302 {ECO:0000313|EMBL:OYD69279.1,
RC   ECO:0000313|Proteomes:UP000215121};
RA   Pelletier D.;
RT   "Populus root and rhizosphere microbial communities from Tennessee, USA.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OYD69279.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NPJZ01000001; OYD69279.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A235G6R7; -.
DR   OrthoDB; 9779233at2; -.
DR   Proteomes; UP000215121; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1630; -; 1.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR010721; UstE-like.
DR   PANTHER; PTHR32251; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR   PANTHER; PTHR32251:SF15; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295); 1.
DR   Pfam; PF06966; DUF1295; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        31..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          140..210
FT                   /note="Steroid 5-alpha reductase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50244"
SQ   SEQUENCE   259 AA;  28252 MW;  C3580E50F5BE6ED2 CRC64;
     MGTVALASLL AIVVTMAVTA VIGVRIGRHN VVDVSWGVGF VVIAAVSAAV GTGDLWRRLL
     MLALVGMWGL RLASHMAVRS RGKGEDPRYE ELLGKASGNR TLHAIRKIYV TQGISLWFVS
     LPVQVSAQSS GGFNVIVVLG VLLWLLGVTF EAVGDRQMAA FKSDPGSRGH IMDQGLWAWT
     RHPNYFGDAC VWWGIFLVAA SAWPGVLTIL SPVAMTYFLV FATGARLLER HMAQRPGYRE
     YQERTSYFVP RRPRSAPGA
//