ID A0A238BM76_9BILA Unreviewed; 406 AA.
AC A0A238BM76;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN ORFNames=X798_06466 {ECO:0000313|EMBL:OZC06549.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|EMBL:OZC06549.1, ECO:0000313|Proteomes:UP000242913};
RN [1] {ECO:0000313|EMBL:OZC06549.1, ECO:0000313|Proteomes:UP000242913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red Deer {ECO:0000313|EMBL:OZC06549.1};
RA Mitreva M.;
RT "Draft genome of the nematode, Onchocerca flexuosa.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC {ECO:0000256|ARBA:ARBA00037788}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; KZ270091; OZC06549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238BM76; -.
DR Proteomes; UP000242913; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd09762; HSDL2_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000242913}.
FT DOMAIN 300..399
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 406 AA; 44528 MW; 4A40CF435D30B394 CRC64;
MKFAISRRFA GRTVVITGAS RGIGKEIALK LAKDGANIVV AAKTTEAHPK LPGTIYSAVE
DIEKAGGKGL ACVVDVRDEQ SVTKAISEAI QKFGGIDILI NNASAISLTG TLQTTMKKFD
LMHQINTRGT FLMSQKCIPF LKNGKNPHIL NISPPLNMAK QWFANHVAYT MAKYGMSMCV
LGMHEELRPF NIAVNALWPR TAIWTAAMEM ISAGSARNNC RKPTIMADAA YAVLSRDSTN
YTGNFVIDEE ILREEGIQDF DQYSINPGAT LLEDFFLSDV AEIGSPETAT SILSVDAMIN
EVKQRITPDI VQKIQAIYQF DVVEGAKIHS VYFNLKNGQA GIHKTLNNTK DVDVRFITDP
QTLCKLFNGK ISPTVAVASE KFKIEGNMEK ALLLSQLFKS SNKNKL
//