ID A0A238BT36_9BILA Unreviewed; 387 AA.
AC A0A238BT36;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Proteasome subunit alpha type-2 {ECO:0000256|ARBA:ARBA00021337};
GN ORFNames=X798_04524 {ECO:0000313|EMBL:OZC08463.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|EMBL:OZC08463.1, ECO:0000313|Proteomes:UP000242913};
RN [1] {ECO:0000313|EMBL:OZC08463.1, ECO:0000313|Proteomes:UP000242913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red Deer {ECO:0000313|EMBL:OZC08463.1};
RA Mitreva M.;
RT "Draft genome of the nematode, Onchocerca flexuosa.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The proteasome is a multicatalytic proteinase complex which
CC is characterized by its ability to cleave peptides with Arg, Phe, Tyr,
CC Leu, and Glu adjacent to the leaving group at neutral or slightly basic
CC pH. The proteasome has an ATP-dependent proteolytic activity.
CC {ECO:0000256|ARBA:ARBA00002000}.
CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000256|PROSITE-
CC ProRule:PRU00808}.
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DR EMBL; KZ270008; OZC08463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238BT36; -.
DR Proteomes; UP000242913; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd06466; p23_CS_SGT1_like; 1.
DR CDD; cd03750; proteasome_alpha_type_2; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023332; Proteasome_alpha-type.
DR InterPro; IPR000426; Proteasome_asu_N.
DR InterPro; IPR001353; Proteasome_sua/b.
DR InterPro; IPR007699; SGS_dom.
DR PANTHER; PTHR11599:SF16; PROTEASOME SUBUNIT ALPHA TYPE-2; 1.
DR PANTHER; PTHR11599; PROTEASOME SUBUNIT ALPHA/BETA; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF00227; Proteasome; 1.
DR Pfam; PF10584; Proteasome_A_N; 1.
DR Pfam; PF05002; SGS; 1.
DR SMART; SM00948; Proteasome_A_N; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1.
DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1.
DR PROSITE; PS51048; SGS; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PROSITE-
KW ProRule:PRU00808}; Reference proteome {ECO:0000313|Proteomes:UP000242913}.
FT DOMAIN 215..300
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT DOMAIN 303..387
FT /note="SGS"
FT /evidence="ECO:0000259|PROSITE:PS51048"
SQ SEQUENCE 387 AA; 43633 MW; C616FB7E4BC7D9E6 CRC64;
MGESDHYGFS LTTFSPSGKL MQIEYALNAV KNGQPSVGLR ASDGVVLATE NKISILYEDQ
PKVEKISQHI GCVYSGMGPD YRILVKKARK LAMEYELMYG EEIPTTQLVT KLAAVMQEYT
QSGGVRPFGV SMLVAGWDHE PNPGRPLLFQ CDPSGAYFAW KATALGKNDV NAKTFLEKRF
SDALELDDGI HTALLTLRES FDVGMTEDNV EIAVCNKNGY DFYQTETHVF VTILKRGLTL
EQCKAHYIDG YLKVVAMNEV LLNIRLSHPI NPTSLELKCS SSKVELKMAK LTSDQWETLE
EKSEENKNKP ALISWDKFAQ EAEDDEEKED VNILFQKLYK DADDDTRKAM IKSYTESGGT
VLSTNWKEIS KKRTEIRPPD GMEFKKW
//
