ID A0A238D2P2_THIDL Unreviewed; 723 AA.
AC A0A238D2P2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN Name=topB {ECO:0000313|EMBL:SBP87502.1};
GN ORFNames=THIARS_60215 {ECO:0000313|EMBL:SBP87502.1};
OS Thiomonas delicata (Thiomonas cuprina).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Thiomonas.
OX NCBI_TaxID=364030 {ECO:0000313|EMBL:SBP87502.1, ECO:0000313|Proteomes:UP000214566};
RN [1] {ECO:0000313|EMBL:SBP87502.1, ECO:0000313|Proteomes:UP000214566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16361 {ECO:0000313|EMBL:SBP87502.1,
RC ECO:0000313|Proteomes:UP000214566};
RA Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FLMQ01000055; SBP87502.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238D2P2; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000214566; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SBP87502.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000214566};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 649..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 78266 MW; 1A7844E6235DB662 CRC64;
MRLIIAEKPS VAQAIAGVIG GARRNDGYIE CPQAKTRVTW CFGHLLEQAR PEDYVAGGKV
LASHLPVVPI AWKLSPRDGG AGKQVKVIRD LLKDTSEVVN AGDADREGQL LVDEVLLFLN
WKGKTSRLWL SSLDDESVRR ALVSLKNNDA MRPLYESALA RQRADWLMGM NASIALSRNL
QACGVQGAWS VGRVQTPTLA LLVDRQRDIQ NFKPRDHYQV QAALDGDIRA LWQIPEDLQT
EDGLLLDKSA AEACAQAVQG RRATVSAFTR KAGERQAPMP YALSTLQKTA SSRLGLSAKD
TLAAAQNLYE AKLASYPRSD CPWLPAEMHV AAAQIIRALG AADIAGIDPE RRHPAWNTAK
VEAHHGIIPT GRSLAEASGL SGNAKAVYGL LRESYLRLFM PPETFETREA LFTFPGGERF
KASARIVQEP GWTQLGQGDS SAEDGEPEQP ARLPILTEGQ QLTCESAQVQ AKRTSPPKPY
TDGTLIAAMT GVHKLVTDSK LKARLKETSG LGTEATRASM IEVLIAREYA ERKKKEIHPT
EHGVQLIDML RKVAPDLADP GTTALQEDAL AAIASARSTF DEFMTAQIDA VRESTQKLLG
GQLGATPAIL HACPACGGGR CAQRTSKAGA TYHRCLDCDA AFGDDGGKPG KRFEDKHQSE
GAAAKAPASG PKCLSCKKPT FKNETKTGKP YYRCGGCKGA WWPDRKDEGK LGTKWEERAG
ARA
//
