ID   A0A238FDE4_9BASI        Unreviewed;      1136 AA.
AC   A0A238FDE4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE            EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN   ORFNames=BQ2448_2795 {ECO:0000313|EMBL:SCV71207.1};
OS   Microbotryum intermedium.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum.
OX   NCBI_TaxID=269621 {ECO:0000313|EMBL:SCV71207.1, ECO:0000313|Proteomes:UP000198372};
RN   [1] {ECO:0000313|Proteomes:UP000198372}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jeantristanb JTB J.-T., Ricardo R.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
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DR   EMBL; FMSP01000007; SCV71207.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A238FDE4; -.
DR   STRING; 269621.A0A238FDE4; -.
DR   OrthoDB; 2786490at2759; -.
DR   Proteomes; UP000198372; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10812; GH38N_AMII_ScAms1_like; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198372}.
FT   DOMAIN          554..636
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1136 AA;  126737 MW;  CD99A100149936B3 CRC64;
     MASYANSKPL YPVQAEGPKP LHFRGLTLGR LEHFEGGPYN NIHSVLYEHR IDDPEHIQIE
     SWSSPGRTKT PFKEAIEQKY KPAKKGDHFG PSWSHHWFRV TINLPRSWAD AERVQLEWDP
     GCEAMVYDTE GLTLQGITGG FGVDRHIDFI LDPKKRNSTY KIYIEVACNA MFGNGKPEVN
     DPPDNSRMFQ LATADLVVPR MNAWQLRWDF RTMNDLARAL PENSPLGNKC LEVCNAIMNT
     FKADDLSTIA KCRKLAEKVF GQGWEELGHK IFKGDPADAM TWGIGNCHID TAWLWPYSAT
     RQKTARSWST QLDLMDRYPE YTFVASQAQQ FKWLEEDYPL LFQKIKGRVE SGKFQPIGAA
     WVECDTNMPS GEALCRQFLY GQRYYKSRFG EYTRTFWLPD SFGYSSQLPQ LCRLAGCDFF
     FTQKLSWSQF NAPVHTSFKW VGQDGSQILT HMTPVNTYTA QASVGDVRNS INNHKSLQSG
     AATGLLAFGN GDGGGGPLSH MLENLRRCRA VADHSGELPK VTMGKTVDLF YEDILNKSEG
     GTTLPTWNGE LYLELHRGTA TSHGSIKKGN RKSEILLREV EYAATLASVW KSTKNGYSYP
     KDTIDPLWEG VLLNQFHDVL PGSGISLIYE DAEKIYAETA EKGGALLEEA LRVLLPGSVR
     ADDANAEGDE LVAVNTTNFA RRDLVKIPLA GARALADAAI QLSHDGAAYV LFENDGAQPL
     SSATSIEALN LGPARARAVG SDYVLSNSQL KVTVNKKGRI TSLIDIELNR ELIDEGKAAG
     FVIFEDRPLN WDAWDVDVFH LETKEDVDAS SVEVLEDGPM RAAIVATYHF GKSKVKATIS
     LDAIAPVAKQ DALSLVRFEL EVVWYEKHRF LKWEVPLAIS SEYATYENQF GVCQRPTTRN
     TTWDRAKFEV VGHKFADLSE FGYGVALLND CKYGYACEGN VLRLSLLRAP TVPDAHTDEG
     YHAFSFALLA HRGSFVESDV PIAGWLFNQP PQVRRMPRVA FQAALARDAV PQPFKLEGTR
     NIMLDTIKRG EEDHFGGKGS APQTVVLRFY EAFGGHGQVD VISPLAIESA TICDILERDL
     EDVEVVQLLK SGKGMSSFKL KFRGFQVVSV KVTLATSGGK KDEMKGSKRD EQWLAL
//