ID   A0A238L4M6_9RHOB        Unreviewed;       770 AA.
AC   A0A238L4M6;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Heparin-sulfate lyase {ECO:0000313|EMBL:SMX49979.1};
DE            EC=4.2.2.8 {ECO:0000313|EMBL:SMX49979.1};
GN   Name=hepC {ECO:0000313|EMBL:SMX49979.1};
GN   ORFNames=PEV8663_04425 {ECO:0000313|EMBL:SMX49979.1};
OS   Pelagimonas varians.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Pelagimonas.
OX   NCBI_TaxID=696760 {ECO:0000313|EMBL:SMX49979.1, ECO:0000313|Proteomes:UP000220836};
RN   [1] {ECO:0000313|EMBL:SMX49979.1, ECO:0000313|Proteomes:UP000220836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8663 {ECO:0000313|EMBL:SMX49979.1,
RC   ECO:0000313|Proteomes:UP000220836};
RA   Song R., Chenine A.L., Ruprecht R.M.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FXYH01000025; SMX49979.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A238L4M6; -.
DR   OrthoDB; 9772435at2; -.
DR   Proteomes; UP000220836; Unassembled WGS sequence.
DR   GO; GO:0015021; F:heparin-sulfate lyase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.70.98.70; -; 1.
DR   Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR008929; Chondroitin_lyas.
DR   InterPro; IPR012480; Hepar_II_III.
DR   InterPro; IPR032518; HepII_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR012364; Oligosacch_lyase.
DR   PANTHER; PTHR38045; CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE; 1.
DR   PANTHER; PTHR38045:SF1; CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE; 1.
DR   Pfam; PF16332; DUF4962; 1.
DR   Pfam; PF07940; Hepar_II_III; 1.
DR   PIRSF; PIRSF034409; Oligosach_lyase; 1.
DR   SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:SMX49979.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000220836}.
FT   DOMAIN          21..449
FT                   /note="Heparinase II N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16332"
SQ   SEQUENCE   770 AA;  87624 MW;  81E84ADF43F9A6AD CRC64;
     MSASENYLDQ PRAGRLNIQY APVDGVVMAE NPPRFMWLPV VEEEATYVLR VARDDSYTDA
     HVFSDLPLNF LTPDVVFEPG EYVWSYAVWD AKAKGPATEW SKNRSFSIAE GATEVPLAGR
     GARYAKSDMA HPRLWLGPKE LAAFKKDLAK DADHCAWSTF FEKSAAPWMD RPVMDEPVGY
     ENHQRTPPVW RQTYIDCQEL MYAIRHLAVA GQVLEDSAML DRAKEWLLAA ADWDPAGTTS
     RAYTDEWAFR VTLALGWGYD WLYNELSDEE RTKVRTALLI RTREIAEHII DHANIHLFPY
     DSHAVRAVSA VLVPCCIAML DEEPEAREWL DYSIEFLSTV YTPWGDDQGG WAEGPHYWMT
     GQAYLIDAAN LLKAFTGFDL YERPFFQKTG DMPLYTKAPD TRRATFGDDS TMGDLPCLKI
     GYNLRQYAGV TGNGAYQWYY DEIKRNDPGT EMAFYNWGWW DFNFDEMLYR QQWPIVEAKA
     PAADDRLRWF KGIGWVAIQS KMDVPEEHLQ FVFKASSFGS ISHSHGDQNA FCLAAYGEDL
     AIQSGHYVAF NSSMHQKWRR QTISKNAILI NGKGQYADRD KAKQMQSTGQ VLAAEERDDH
     IYIKGDATAA YQSLSPEVTR VHREIYFVNN SYFVIVDTID ADEPVTIDFR IHANGPFQLG
     KGSFRYTGDK AGFYGEVLWS EAGKPEISQE TGFPGVDMKE VEGLPISTCM TASYPKAKRH
     RIATLLVPYS TTDPKRIFHF LDDQGYDCDL YFTDADENSF KVVVEKLAKA
//