ID A0A238LIJ2_9RHOB Unreviewed; 473 AA.
AC A0A238LIJ2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN Name=algA_2 {ECO:0000313|EMBL:SMY09224.1};
GN ORFNames=LOM8899_03389 {ECO:0000313|EMBL:SMY09224.1};
OS Flavimaricola marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Flavimaricola.
OX NCBI_TaxID=1819565 {ECO:0000313|EMBL:SMY09224.1, ECO:0000313|Proteomes:UP000201613};
RN [1] {ECO:0000313|EMBL:SMY09224.1, ECO:0000313|Proteomes:UP000201613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 8899 {ECO:0000313|EMBL:SMY09224.1,
RC ECO:0000313|Proteomes:UP000201613};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; FXZK01000008; SMY09224.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238LIJ2; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000201613; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000201613};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..282
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 318..468
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 473 AA; 50636 MW; 0F4EC0BFC54DCE78 CRC64;
MITPILLCGG SGTRLWPLSR KSYPKQFAKL MGEESLFQAS SLRLSGEGFG APVILTGEPF
RFIVTEQLAA VEQAPAGILI EPEGRNTAPA VLAAALWLER QDPQALMLVA PSDHVIPDAA
AFRAAVQAAV PRAQAGDLVT FGITPDRPET GYGYLELAKG ADAGAATPQP LARFVEKPDA
ARATEMLAAG NFLWNAGIFL FSAASIVAAY KAHAPELMAG VTAALDGAKS DLGFTRLAAE
PWGALEDISI DYAIMEKAEN LAVMPYTAGW SDLGGWDAVW RESGPDSDGN VCSDHATAIG
CADTLLRSET PGQEVVGIGL EDMMVVAMSD AVLVAPKSEA QRVKEAVAAL KAKGASQAVQ
LPRDYRPWGW YESLIIGGRF QVKRIVVHPG AALSLQSHHH RSEHWIVVEG TARVTVDEDV
RLLSENQSVY IPLGAVHRME NPGKVPMVLI EVQTGSYLGE DDIIRYEDVY ARE
//
