ID A0A238TAQ7_9NEIS Unreviewed; 736 AA.
AC A0A238TAQ7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:SNB51237.1};
GN ORFNames=KEBURONENSIS_00069 {ECO:0000313|EMBL:SNB51237.1};
OS Kingella negevensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Kingella.
OX NCBI_TaxID=1522312 {ECO:0000313|EMBL:SNB51237.1, ECO:0000313|Proteomes:UP000215450};
RN [1] {ECO:0000313|EMBL:SMQ11714.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kingella_eburonensis {ECO:0000313|EMBL:SMQ11714.1};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SNB51237.1, ECO:0000313|Proteomes:UP000215450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kingella_eburonensis {ECO:0000313|EMBL:SNB51237.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FXUV01000001; SMQ11714.1; -; Genomic_DNA.
DR EMBL; FXUV02000001; SNB51237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238TAQ7; -.
DR STRING; 1522312.GCA_900177895_02124; -.
DR OrthoDB; 5905204at2; -.
DR Proteomes; UP000215450; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000215450}.
FT DOMAIN 13..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..571
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 736 AA; 82407 MW; FBB58939E9CC3F50 CRC64;
MFAPQESHSS LLNNLNPEQL AAVTYPPQSA LVLAGAGSGK TRVLTTRIAW LLQNGMANVH
SIMAVTFTNK AAKEMKIRLS AMLPINLNAM WLGTFHGLCH RFLRLHYRDA GLPQTFQILD
SADQLTLIKR MLKQMNIAEE TLAPRVLMGF INAQKESGLR SGSLNSNNPH ENRMIQCYAE
YEAICQREGV VDFAELMLRS YEILNTNEVL RTHYQQRFKH ILVDEFQDTN KLQFAWLKLM
AGEHSAIFAV GDDDQSIYRF RGANVGNMAD FLRENHIAAP IKLEQNYRSV GNILAAANAV
IENNEERLGK NLRTEAENGE KIRFLSAYND LEEASFIVEE CSSLKREDVP LSQIAVLYRS
NAQSRVIEQQ LFQAAIPYKI YGGLRFYERQ EIKHALAYLR LAVNPDDDNA LLRVINFPPR
GIGARSIENI QAAALEQGMS LWQAACGMGG KAAKIAAFVQ LIDALREQVG TLTLPDILQN
VLDMSGLYRH YQTQKQVAEQ ERTENLDELI NAAHFFKPED STFETLPENA ADSPEFAILA
FLSNASLESG EMQAGEGQEA VQLMTVHAAK GLEFDVVFLT GLEEGRFPSE LSLNERGGLQ
EERRLMYVAI TRARKRLYLT MAQQRMLHGS MQFGVQSRFV EEIPDDLLRY LSAPKKAASA
FSGSLKSDLQ PEKDIYQENT REYDGFKLGD NVRHAKFGVG VIVAALDKGK SAKLTINFGA
QGMKELDSAV AKLEKV
//
