ID A0A238U4M2_9FLAO Unreviewed; 763 AA.
AC A0A238U4M2;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=TJEJU_0170 {ECO:0000313|EMBL:SNR13976.1};
OS Tenacibaculum jejuense.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tenacibaculum.
OX NCBI_TaxID=584609 {ECO:0000313|EMBL:SNR13976.1, ECO:0000313|Proteomes:UP000215214};
RN [1] {ECO:0000313|EMBL:SNR13976.1, ECO:0000313|Proteomes:UP000215214}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=type strain: KCTC 22618 {ECO:0000313|Proteomes:UP000215214};
RA Sun Z.S., Albrecht U., Echele G., Lee C.C.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
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DR EMBL; LT899436; SNR13976.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238U4M2; -.
DR KEGG; tje:TJEJU_0170; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000215214; Chromosome tjeju.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF11; PENICILLIN-BINDING PROTEIN 1B; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000215214};
KW Transferase {ECO:0000313|EMBL:SNR13976.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..242
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 425..677
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 738..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 86656 MW; 101993F491B9D42D CRC64;
MSEKKTISFR SYIKWFWGLL LGGILSICLV FLFASWGVLG KLPTFEQLEN PQNDLATEII
SSDGKTIGKY YLKANRTPIK YKDLPDNLVK ALVATEDERF YEHSGIDFRG LARAIAKLGK
GGGASTITQQ LAKNLFTKRA SSNKIKRIIQ KVKEWVIAVR LERQYTKKEI ITMYLNTQDF
IFNAVGIRSA ARIYFGKEPK DLDLQESAII VAMLKNPRQF NPNRKISKKK SLNRRNVVFA
QMLKNGFITQ QEKDSLQKLP LKIKFTPESH SDGLATYFRE HLKKFLKDWA KKNPKADGEL
YDIYKDGLKV YVTIDSRMQQ YAEEAMTEHM SNLQKYFFAE HKKNKNAPFY DIERDDIRKI
INRAKTNSDR YKRMKAAGKS DKEIEKAFNT KTDMTVFSWK GDRDTVMTPY DSIRYYKYFL
RSGLVSIEPQ TGHIKAWVGG INNKHFKYEA VDQQKRQVGS TFKPFVYATA INQLKRSPCD
KLPNTPYTIP KEKYGMDDDW TPKNAGNKYG GELTLQQALA KSVNVITARL IDEVSPINVA
RLAKSAGIST EFQANPSIAL GAIDLTLLEM TSAYSTFANK GMRVTPIFIT QIEDKNGTVL
ETFVPKTKEV LSEESAYVAL NLMEGVTKFG SGARLRSKYT RPKFITGYPY EFNNAIAGKT
GTTQNQSDGW FMGTVPNLTT GVWTGGEDRS IHFVGLDKGG GASMSLPTWA IFMRKCYADK
SLKISKADFE EPSDLSINVD CKKHEEKKDE KKDAEKVQNA DDF
//
