ID   A0A238U714_9FLAO        Unreviewed;       802 AA.
AC   A0A238U714;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Putative 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SNR14947.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:SNR14947.1};
GN   Name=fadN {ECO:0000313|EMBL:SNR14947.1};
GN   ORFNames=TJEJU_1199 {ECO:0000313|EMBL:SNR14947.1};
OS   Tenacibaculum jejuense.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Tenacibaculum.
OX   NCBI_TaxID=584609 {ECO:0000313|EMBL:SNR14947.1, ECO:0000313|Proteomes:UP000215214};
RN   [1] {ECO:0000313|EMBL:SNR14947.1, ECO:0000313|Proteomes:UP000215214}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=type strain: KCTC 22618 {ECO:0000313|Proteomes:UP000215214};
RA   Sun Z.S., Albrecht U., Echele G., Lee C.C.;
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; LT899436; SNR14947.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A238U714; -.
DR   KEGG; tje:TJEJU_1199; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000215214; Chromosome tjeju.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000313|EMBL:SNR14947.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000215214}.
FT   DOMAIN          8..206
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          209..308
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   802 AA;  89033 MW;  4E5B790BCB68E807 CRC64;
     MSKRRIKKVA IIGSGIMGSG IACHFANIGV DVLLLDIVPR ELTDKEKAKG LTLEDKVVRN
     RLVNDALTAS LKSKPSPIYN KKFADRITTG NIDDDLHLIK DVDWVMEVVV ERLDIKQSVF
     EKVEKYRTPG TIISSNTSGI PIKFMNEGRS EDFRKHFAVT HFFNPPRYLK LFEVVPGPDC
     KQEVTDFLME YGDKFLGKTS VLAKDTPAFI GNRIGIFGIQ SLFHQVKELG LTVEEVDKLT
     GPVIGRPKSA TFRTVDVVGL DTLVHVANGI YDNCPDDEAH DLFKLPDFIN TMMENKWLGS
     KTKQGFYKKS VNAEGKKEIL TLDLDTMEYR SKKRAKFATL ELTKTIDKPI DRFKVLVGGK
     DKAGEFYRKN FAAMFAYVQN RIPEISDELY RIDDAMKAGF GWENGPFEIW DAVGVEKGIE
     LMKAEGKEPA AWVTEMVAKG ETAFYTVKDG ATYYYDVNEK AQVKKPGQDA FIILDNIRKS
     KEVFKNSGVV IEDLGDGILN CEFQSKMNTI GGDVLAGLNK AVDLAEKDFE GLVVGNQGAN
     FSVGANIGMI FMMAVEQEYD ELNMAIKYFQ DTMTRMRYSS IPVIAAPHGM ALGGGCELSL
     HADKVVAAAE TYMGLVEFGV GVIPGGGGSK EMALRASDTF RKGDVQLNVL QEYFLTIGMA
     KVSTSAYEAF DLGLLQQGKD VVVVNRDRQI AEAKKHALLL ADAGYTQPVH RNDVLVLGKQ
     ALGAFMVATD SMQASRFISE HDQKIANKLA YVMAGGDLSE PTKVSEQYLL DIEREAFLSL
     TTERKTLERI QHMLKTGKPL RN
//