ID A0A238VHS1_9PSEU Unreviewed; 2307 AA.
AC A0A238VHS1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SNR33223.1};
GN ORFNames=SAMN06265360_102209 {ECO:0000313|EMBL:SNR33223.1};
OS Haloechinothrix alba.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Haloechinothrix.
OX NCBI_TaxID=664784 {ECO:0000313|EMBL:SNR33223.1, ECO:0000313|Proteomes:UP000198348};
RN [1] {ECO:0000313|EMBL:SNR33223.1, ECO:0000313|Proteomes:UP000198348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45207 {ECO:0000313|EMBL:SNR33223.1,
RC ECO:0000313|Proteomes:UP000198348};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
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DR EMBL; FZNW01000002; SNR33223.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000198348; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR004136; NMO.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF03060; NMO; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000198348};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNR33223.1}.
FT DOMAIN 664..1110
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1640..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1773..1820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2307 AA; 239470 MW; 7C0C0B04959DD83A CRC64;
MSAAGPRPDV LLGVNPCGTP DARMCAAVSA AGGLGVIDLG CGDARSRNEL VRVVEGGNTD
RFGVRVDGEC ALTYEEVAEL LGDSAGALEV VVLGWDAPWE PWQIADRVVV LVEVASRQEA
VVARESGADG VVAKGNEAGG RVGELGSFVL LQQLLSEPRH GLPVWVCGGI GPQTAAAAVT
GGAAGVVLDT QLALLPESEL PGYIRGTLAA SDGTDSRVVD GRRVIPARVP GTGRGAGNGG
AGAEAVHIVA GQDAGLATRF VEHYGGVARA VRSVLAAMHG TAEPGNHADL RAGSPLSGRL
GGDLPIAQGP MTRVSDQADF AAAVAGAGAT PYLALALSSG EQVSDLLERT DARLGERPWG
VGILGFAPDD LRAAQLNAVL RFRPRTAVIA GGRPDQARDL EDAGISTFLH VPSPGLLEQF
LDAGARKFVF EGSECGGHVG PRSCFTLWQQ QLGVLRDFIA AGGAGEELEV LFAGGIHDAR
SSAMVSAMAG PLAGEGAAVG ILMGTAYLFT EEAVACGAVG PVFQQVAREA QHTELLETAP
GHATRCVESP FTSEFTSIAA NLRDQGLDRR AVWERLEQLN VGRLRIASKG VRRDGDSLVA
VDDAEQHRSG MFMAGQVATL RHGLTTLAEL HEEVTGGAAA FRDASIDRIR RCIGDAESPP
EPEPLDIAIV GMSSMFPQAA TLEEYWSNVV SNVGAITEVP PERWDVDTYF VAQDAPATPT
GGDSTPSKWG GFLPDIPFDP TRFGIPPGSL ASIEPVQLLA LHAADRALVD AGYARTGFDR
SRTGVVFGAA AGSDLANAKT LRMVLPSYSG ELPEELDNCL PRLTEDSLPG RLSNVIAGRI
ANRLDLGGSN YTIDAACAAS LAALDTACKE LATNSADMML CGGADLHNAI EDYLLFASVG
ALSPTGSCKT FDSSADGIAL GEGVACLALK RLSDAERDGD RVYAVIKGVA GGSDGKALGL
TAPRPEGQRR ALDRAYGLAG VSPRQVGLVE AHGTGTVVGD RTELTTLTTL FDEAGTEPGS
CVLGSVKSQI GHTMCAAGLA GLIKSAMAIY TGILPPTRAI GEPNHAWSPE HSPFVFREQA
VPWAAAPRDR IAGVSAFGFG GTNFHAVLAG HSAADSNRHG LWNWPAELFT FRGADRASAH
GELEWLSALV ETNESHGRPW RLRDLACTAS ARSDRGTEPV QVAIVAADLD ELAGSLRAAL
DGRTDVDGVV FRATGEEPEG KLAVLFPGQG SQYPGMMAEL FGAFDELRRI AVRDPDTHAA
MFPPAAFDAG TARDQRERLR DTRMAQPALG VTGLGVHYLL GRLGIRPDAY AGHSYGELVA
LAAAGAIDEH SLPALSKERA DAMVTAAGSD PGGMAAVRAD RETVDGVLDG APSLGSVVVA
NYNAPGQVVV SGPATGLDRA IELLSAMGLP VTRLNVACAF HSPVVEDAAG LFATALEPLP
VGAPRTQVWS NRTASAYPGD GKAVRSELAA QIAAPVDFCG QIEAMYADGF RVFLEAGPGS
VLGGLVGAVL GDRPHTVVGC DEAGGGLRGF LRAAATLAVS GSDVRTGWLF TGRDARDVST
SRAPGRPRWT VNGHLARTAD GKVVPGGLFP ADEVKGTVMF GDGPVGDTGP TDEVMSEFLR
NSREMVAAQR DVMLSYLGAD PGVPLEVPGR TDGERRAMDA GRDADRRTGQ DDGQLQEPPP
ERRVPDDRVG ADAGGQASAG DELARVVDVL ARRTGYPPEM IEPDLDLEAD LSVDSIKRTE
VAGELIAGSP GGAPVSAEDL ARTRTARAMA EALSGSAATA GTAPDTAGRD GAAGESATPA
GENADAPATP VDAGRVPATQ PPVRHVLRLE DAEAGDTEPA DVLVGARVAV VGGCELAEHV
ADELSARGAT AWVVADGTRY AAELESDDGD LDGLVVLNAL DNDAEPSLPR DYPLFRCALA
RRPRWVLAVA PHGNGARASL GLRGLVRTLY KEHPGTRVRL VEVDRDEPVG MLASTVLSEM
LTAGPDPVVA VEGGSRRSFR MVVAERGAPH ADDRANGRPD PVSDMGLGPD SVVLLIGGAR
GITARVAQRL AADSGCRIRL AGRTPPPSEP EDAELAAAAD LPALRSVLAR RGRAGPQDID
LQAREILARR EVTDTLAELS ETAADVRYHT VDVTEPGSVR GLVKEIYAED GRIDGVVYAA
GVIEDRLVAD KDTESFQRVY STKVDGAGEL LEGLADGGEP PSFVVLFGSI AAALGNRGQA
DYAAANDALE GIAARSPRPL SGRVRTIHWG PWAPAAEHGG MVTPELERSY AERGVSLMDP
DAAIGELFAE LAWGPADGVP IVTASGW
//