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Database: UniProt
Entry: A0A238VME9_9RHOB
LinkDB: A0A238VME9_9RHOB
Original site: A0A238VME9_9RHOB 
ID   A0A238VME9_9RHOB        Unreviewed;       600 AA.
AC   A0A238VME9;
DT   25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=SAMN06265378_102429 {ECO:0000313|EMBL:SNR35378.1};
OS   Paracoccus sediminis.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Paracoccus.
OX   NCBI_TaxID=1214787 {ECO:0000313|EMBL:SNR35378.1, ECO:0000313|Proteomes:UP000198409};
RN   [1] {ECO:0000313|Proteomes:UP000198409}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26170 {ECO:0000313|Proteomes:UP000198409};
RA   Varghese N., Submissions S.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR   EMBL; FZNM01000002; SNR35378.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A238VME9; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000198409; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03482; MutL_Trans_MutL; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}.
FT   DOMAIN          220..338
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          413..556
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   600 AA;  63946 MW;  8BCD965059A092FF CRC64;
     MNSQTPHIRP VIRQLDEATA NRIAAGEVVE RPASAVKELV ENALDAGATR IDIAIQDGGK
     RLIRVCDNGC GMAPDDLPLA LSRHATSKID GSDLLAIRSF GFRGEALPSL GAVGRLTITS
     RVRSGDGATI AVTGGAIAPV RPSAANPGTV VELRDLFYAT PARLKFLRGD RAETMAVAEC
     VRRLAMAEPF AGFTLTADDR EILRCDAETG DPLGALHARL ARVMGRDFID NAIALDAERD
     GLRLSGFAAL PTYSRGAAVA QHLYVNGRPV RDKMLTGALR AGYMDVLASG RHPAAVLYLA
     CDPQLVDVNV HPAKAEVRFR DPQSARGLLV SALRHGLAGA GHRASSTVGD AAMAAFRAET
     TAPRAYPMDY RPPAPAIRAS LDLQAPVPGF AEAPSARAED PVAVPDDAPL GAARAQIHEN
     YIIAQTVDGL VIVDGHAAHE RLVYERLKAQ AAAAGIARQV LLIPEIIALP DHDAARILAI
     APDLAELGLV IEPFGGGAVA VREIPAMLAR LDTQALIRDI LDDLVELDAS DRLRGRIDAV
     LSSMACHGSV RSGRRMTAEE MNALLRDMER TPRSGQCNHG RPTWVKLRLP DIERLFGRKD
//
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