ID   A0A238VRH0_9FLAO        Unreviewed;       410 AA.
AC   A0A238VRH0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   ORFNames=SAMN06265376_101262 {ECO:0000313|EMBL:SNR36952.1};
OS   Dokdonia pacifica.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Dokdonia.
OX   NCBI_TaxID=1627892 {ECO:0000313|EMBL:SNR36952.1, ECO:0000313|Proteomes:UP000198379};
RN   [1] {ECO:0000313|EMBL:SNR36952.1, ECO:0000313|Proteomes:UP000198379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25597 {ECO:0000313|EMBL:SNR36952.1,
RC   ECO:0000313|Proteomes:UP000198379};
RA   Kim H.J., Triplett B.A.;
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in both transcription termination and
CC       antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC       dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
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DR   EMBL; FZNY01000001; SNR36952.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A238VRH0; -.
DR   OrthoDB; 9807233at2; -.
DR   Proteomes; UP000198379; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   CDD; cd02134; KH-II_NusA_rpt1; 1.
DR   CDD; cd22529; KH-II_NusA_rpt2; 1.
DR   Gene3D; 3.30.300.20; -; 2.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.30.1480.10; NusA, N-terminal domain; 1.
DR   HAMAP; MF_00945_B; NusA_B; 1.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR025249; KH_dom_NusA-like.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR030842; NusA_bac.
DR   InterPro; IPR036555; NusA_N_sf.
DR   InterPro; IPR013735; TF_NusA_N.
DR   InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR   NCBIfam; TIGR01953; NusA; 1.
DR   PANTHER; PTHR22648; TRANSCRIPTION TERMINATION FACTOR NUSA; 1.
DR   PANTHER; PTHR22648:SF0; TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA; 1.
DR   Pfam; PF13184; KH_5; 1.
DR   Pfam; PF08529; NusA_N; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 2.
DR   SUPFAM; SSF69705; Transcription factor NusA, N-terminal domain; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00945};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198379};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00945};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00945};
KW   Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00945};
KW   Transcription termination {ECO:0000256|ARBA:ARBA00022472,
KW   ECO:0000256|HAMAP-Rule:MF_00945}.
FT   DOMAIN          6..125
FT                   /note="Transcription factor NusA N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08529"
FT   DOMAIN          233..300
FT                   /note="KH"
FT                   /evidence="ECO:0000259|Pfam:PF13184"
SQ   SEQUENCE   410 AA;  46782 MW;  129C249E0D6D08FD CRC64;
     MENLALIDSF SEFKDDKLID RVTLMAILED VFRSTLKRRF GSDDNFDIII NPDKGDLEIW
     RNRVVVADGE VEDDNAEISL TNARKIEEDF EVGEDVSEEV KLIDLGRRSI LALRQNLISK
     IHEHDNTNIY KHFKELEGEL YTAEVHHIRH RAIILLDDEG NEIILPKDRQ IPSDFFRKGE
     NVRGVIESVE LKGNKPSIVM SRTAPIFLEK LFESEIPEVF DGLITIKKVV RIPGEKAKVA
     VDSYDDRIDP VGACVGMKGS RIHGIVRELG NENIDVINYT NNLNLYISRA LSPARITSLK
     LDDENKTAQV YLKPEEVSKA IGRGGHNIRL AGQLTGYEID VYREGVEEDV ELTEFSDEIE
     GWIIEAFAKI GFDTARSILE QDVDDLVRRT DLEEETVLDV MRILKEEFEE
//