ID A0A238VZ56_9PSEU Unreviewed; 1084 AA.
AC A0A238VZ56;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN06265360_104236 {ECO:0000313|EMBL:SNR39592.1};
OS Haloechinothrix alba.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Haloechinothrix.
OX NCBI_TaxID=664784 {ECO:0000313|EMBL:SNR39592.1, ECO:0000313|Proteomes:UP000198348};
RN [1] {ECO:0000313|EMBL:SNR39592.1, ECO:0000313|Proteomes:UP000198348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45207 {ECO:0000313|EMBL:SNR39592.1,
RC ECO:0000313|Proteomes:UP000198348};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FZNW01000004; SNR39592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238VZ56; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000198348; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198348}.
FT DOMAIN 15..360
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 361..665
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1084 AA; 116129 MW; CF8BC2C9F5D07FA3 CRC64;
MTASPQDVTD ALGLPAPTGE QAEVIAAPAE PGLVVAGAGA GKTETMAARV VWLVANGAVA
PERVLGLTFT RKAARQLAER VRARLRRLVG SGLLDRLDPT GERAARVLAG EPTVLTYHAY
AGRLLSEHGL RIPVQPGARL LSETASWQLA HRVVATWDGD IDTDAVPGTI TARLLGLAGE
LGEHLVDPAE LVSYSERVIN AIEQAPRAKG QRADLPVELT TICERQRFRL QLLPLVAEYE
RRKRAEGALD FADQMALAAR LARDHPEVAE IERERYGAVL LDEYQDTGHA QRVLLRELFG
RGTRTPLPVT AVGDPLQAIY GWRGASAANL ARFTTDFPAT RGTSVGPAAE YGLLTSFRNP
PEVLSLANAL SGPLRGQGAV AELRARPGAA SADVGCALLD DVESERAWVA GEVARRWFEA
CAGGDSPTAA VLVRRRADMA PIAEALRARG LPVEVVGLGG LLDEPEIADL VAVLRVLAEP
LSGSAAARLL TGARMRLGAA DIAALSRRAS ELSADSPGTA EPGADPDTLV SERAESAGLI
DAVDDPGGAE RYSPEGYRRI RTLGADLAAL RGRLDQPLAE LVADVERTLR LDVEAGSRAD
GAGHAHLDAF ARVVTEFAEH ATAPTLLSFV DYLATAEHAE NGLEPGEVTV AEDRVQVLTV
HAAKGLEWRI VAVPHLVDGV FPGKRRSGSW LRTPTELPAG LRGDAADLPK LELSGCADRK
EVIEALRCHE EEFGERHAEE ERRLCYVAFT RAEHSLLVSG YWWNETGSTP RGPSTFLTEI
AERIREAADG DEPLGSIEVW AEQPQEGAAN LFVESARESE WPADPLGERR PAVEEGAALV
RARIDAEADP EGADDGDTED PEGWAADTDV LLAERERARS ATTEVRLPGQ LSVSQLVELA
DDPGALAARL RRPLPSPPNT VARRGTTFHA WLERRFAGGR LFDFDDLPGA ADTGAVEEAG
QEALRQAFEA SEWAVRTPHD VEVPFACDVD GVTVRGRMDA VFADPDGGWT VVDWKTGAVP
SEEAMPALAV QLAAYRVAWA ALAEAPLERV RAAFHYVRSN RTLRPADLLD ADGLRELLRS
VPQG
//
