ID A0A238W1X9_9PSEU Unreviewed; 514 AA.
AC A0A238W1X9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN06265360_1055 {ECO:0000313|EMBL:SNR40123.1};
OS Haloechinothrix alba.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Haloechinothrix.
OX NCBI_TaxID=664784 {ECO:0000313|EMBL:SNR40123.1, ECO:0000313|Proteomes:UP000198348};
RN [1] {ECO:0000313|EMBL:SNR40123.1, ECO:0000313|Proteomes:UP000198348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45207 {ECO:0000313|EMBL:SNR40123.1,
RC ECO:0000313|Proteomes:UP000198348};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FZNW01000005; SNR40123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238W1X9; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000198348; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SNR40123.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198348};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNR40123.1}.
FT DOMAIN 10..203
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 253..476
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 257..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 53969 MW; 63D9671044FC9BE4 CRC64;
MTPAEKSPGR VAFVGSGPGD SGLLTVRAKE LLGSADLVVT NPDVPSTALA YAGDESEVRP
AVGEPGEVAK DLANEADAGR LVIRLVAGDP LTQQAVVGEA HAVARTDAVF DIVPGVSPGV
AVPAYAGIAL GGDYTEIDLR NEVDWAALAS APGTLVLHGT SAHLAEVASA LTEYGRKPET
PVAVTANGTI NTQRTIDTTL SALAADVGET VGPLVVTIGE VAGDRAHLSW WESRALYGWK
VLVPRTKEQA RDMTDRLVGH GSTPHEVPTI SVEPPRSPAQ MERSVKGLVD GRYQWVVFTS
ANAVRAVWEK FSEFGLDARA FSGVKIACVG EATAAKVRAF GIVPDLVPSG DQSSEGLLAE
FDPYDDVFDP VNRVLLPRAD IATETLSAGL TERGWEVDDV TAYRTVRAAP PPAETREMIK
TGGFDAVCFT SASTVRNLVG IAGKPHQRTL VACIGPKTAE TAAEFGLRVD VQASKQLATV
LVDELAEHAA KLRAEGALPP PRKAKRTRRS STSS
//