ID A0A238WDD9_9FLAO Unreviewed; 776 AA.
AC A0A238WDD9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=SAMN06265376_101955 {ECO:0000313|EMBL:SNR44437.1};
OS Dokdonia pacifica.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Dokdonia.
OX NCBI_TaxID=1627892 {ECO:0000313|EMBL:SNR44437.1, ECO:0000313|Proteomes:UP000198379};
RN [1] {ECO:0000313|EMBL:SNR44437.1, ECO:0000313|Proteomes:UP000198379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25597 {ECO:0000313|EMBL:SNR44437.1,
RC ECO:0000313|Proteomes:UP000198379};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
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DR EMBL; FZNY01000001; SNR44437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238WDD9; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000198379; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF11; PENICILLIN-BINDING PROTEIN 1B; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000198379};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..249
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 439..694
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 776 AA; 87832 MW; 126A60235B6B7679 CRC64;
MAKKQIKKKQ ATSTQPNFKK FIKWFWGLFA GGLLAVVLLF LLASWNVFGK LPTFEELENP
ESNLATKILS VDGKQLGTYY NENRTPIKYE DLPQHLVDAL VATEDERYFD HSGIDFKGTA
RAFAFLGSRG GASTVTQQLA KLLFSDTPRS TPERLIQKVK EYVIATRLER QYTKEEIITM
YLNKQGFLFN AIGISSASRI YFNKNVSDLS IEESAVFVAM LKNPRQFNPH RKISREKSKR
RRNQVFKQME KNGFLTTAEK DSLQALPMVV RFTPEGHRDG MATYFRENLK KFLADWIKKN
PKGEDDDGNL EYYNIYRDGL TITTTIDSRM QQMAEEAVKK HMPRLQAEFD KQNIKNKIAP
FRDIEESEIE TIFNNAIKSS ERWRKMKAAG KSESDIRKSF DIKTDMSIFS WQGDIDTVMT
PRDSIRYYKK FLRTGMMSMV PQTGEVRAWV GGINMSHFQY DHVQTGKRQV GSTFKPFLYA
TAVDQLHISP CDTLPNTLFC IAEGKMGNTK EWCPKNSDGK YGGMMTMKDA LAGSVNTISA
RLMNEVGPQP VIDLAEKLGV DVSNIPPVPS IALGTADLSL YEMVSAYSAF ANQGVYIEPQ
IVSTIQDKNG TILYQHVPKT HDVISEEAAY VTLKLMEGVT QSGSGRRLRT GKSNRADYKN
VVTGHPYSFT NPIAGKTGTT QNQSDGWFMG IVPNLVTGVW VGGDDRATHF RTTRYGQGAT
MALPIWGLYM KDVYSNKDLK ISNGKFTKPE DISIEVDCEK YKSQNTDNDD YDELDF
//
