ID A0A238XVL4_9ACTN Unreviewed; 869 AA.
AC A0A238XVL4;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit ClpC {ECO:0000313|EMBL:SNR62730.1};
GN ORFNames=SAMN06264365_10438 {ECO:0000313|EMBL:SNR62730.1};
OS Actinoplanes regularis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=52697 {ECO:0000313|EMBL:SNR62730.1, ECO:0000313|Proteomes:UP000198415};
RN [1] {ECO:0000313|EMBL:SNR62730.1, ECO:0000313|Proteomes:UP000198415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43151 {ECO:0000313|EMBL:SNR62730.1,
RC ECO:0000313|Proteomes:UP000198415};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; FZNR01000004; SNR62730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238XVL4; -.
DR OrthoDB; 9803641at2; -.
DR Proteomes; UP000198415; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Hydrolase {ECO:0000313|EMBL:SNR62730.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:SNR62730.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198415};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..200
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 476..511
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 186..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 94685 MW; ED400C563A91E2A8 CRC64;
MSIGPLGPGG PGQWDDLFAR FFGAAEPRRA AQRIDIARYM SNDARRVLAD AARRAADSGP
GDGGPADLDT DHLLWAVLQQ EPMKQTVRRA GADPQILLSE LELRVGDESA RIASANRRAE
MGAVGLDQPE QVSLTPAAKR ALLDSLQISR AMGASYIGPE HILMALGLNT DSVAGRLLAG
RLDTRAIPNS ETPTGPVAGG QGGSRVTGRA APATPTPTLE QFGVDLTEMA RRGEIDPVIG
RADEIEQAVE ILSRRTKNNP VLIGEAGVGK TAIVEGLAQR IVDGDVPLTL QDKRVVQLDL
AGLVAGTRYR GDFEERLRKI IDEIQASGDG LVVFLDEIHT LVGAGGGGEG GGMDAGNMLK
PALARGRLRV IGATTLDEYR KHIEKDAALA RRFQPVQVGE PSVEDAVAIL RGLRDNYEAH
HQVRITDEAL DAAALLSDRY IADRFLPDKA IDLIDQAGAR VRLRTKMPDA DLRERERQLE
QLSRDRDQAV AAENYEVASQ LRDRINELKA RITGAGAGAD GVPRVTADDI AEMVARATGI
PVAQLTETER DRLLGLEEHL HEHVVGQDDA VTAVAEAVRR SRAGLGDPGR PVGSFLFLGP
TGVGKTELAR SLAEALFGDA DRMVRLDMSE FQERHAVSRL VGAPPGYVGY DEAGQLTEAV
RRRPYSVVLL DELEKAHHDV FNILLQVLDD GRLTDSQGRT VSFKNTVLIM TSNLGSDLIN
GSSRSVGFGG AENGRSPEDD LRDRLDRRLK EQLRPEFINR IDEIIIFRQL ETEQLRKITE
MLLESTRRRL DAQDVRMEIT TAAVDWLADK GYQPEFGARP LRRTIQRELD NRLSKMLLAA
DLAPGRIVRV DVRDGELTFE IESASLSTR
//
