ID A0A238XVU5_9PROT Unreviewed; 624 AA.
AC A0A238XVU5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Kef-type potassium/proton antiporter, CPA2 family {ECO:0000313|EMBL:SNR62474.1};
GN ORFNames=SAMN05192560_0210 {ECO:0000313|EMBL:SNR62474.1};
OS Methylobacillus rhizosphaerae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylobacillus.
OX NCBI_TaxID=551994 {ECO:0000313|EMBL:SNR62474.1, ECO:0000313|Proteomes:UP000198305};
RN [1] {ECO:0000313|EMBL:SNR62474.1, ECO:0000313|Proteomes:UP000198305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ca-68 {ECO:0000313|EMBL:SNR62474.1,
RC ECO:0000313|Proteomes:UP000198305};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; FZOA01000001; SNR62474.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238XVU5; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000198305; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004771; K/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR NCBIfam; TIGR00932; 2a37; 1.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 408..521
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 624 AA; 68756 MW; 7F4080A8965ECB96 CRC64;
MAEAHIPSLL LESVIYLGAA VLAVPIFRRI GLGSVLGYLF AGVVIGPWGL GLVADTDTVL
HFSEFGVVMM LFLIGLEIDP DKLMELRLPI FGMGGLQVLL TAGLVYGVGT AFNLDWRLSL
VVGMGVAMSS TAIAMQVLAE QGALNRPSGR SAFSVLLFQD LAVIPIMILL LVIAPGAHVS
NGVHMDWLAI LKAVALVILL ILGGKYLLRP VLRYIANTGL REIFIAFALF LIIGVSILMT
LVGLSMALGA FISGVLLADS EYRQELELDI EPFKGLLLGL FFISVGMSVN LGMVLQHPVL
IVGLALAFVS FKLVLLFGLA KVFRLNNAGG LMFAVTLSQV GEFAFVIFSA AVDTKVISYE
HSAVLNSVVA ISMVTTPLLL LVYQFAYRRR LQQRRQNRKF DEFDEERPII IAGFGRVGQI
VTRLLTGVGV EPTVIEHDPN QIELMRSFGY RAYYGDITRP DVLRAAGIAN ARLLILAIDN
AEDAIETARY VRQHYPDVKI LARVRNRTYV FDYMDLGIDC VRETFLGAVH LGEKALREMG
YTPFHAYSTA WKFRRHDEGM MRDLHPIHTD MQKVVSYNVR TRQDLQHTLS RDMEEIVAGL
NNNIWGGRSE DSLSESEDGS PQSP
//
