ID A0A238YFD7_9ACTN Unreviewed; 4264 AA.
AC A0A238YFD7;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SNR69508.1};
GN ORFNames=SAMN06264365_104496 {ECO:0000313|EMBL:SNR69508.1};
OS Actinoplanes regularis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=52697 {ECO:0000313|EMBL:SNR69508.1, ECO:0000313|Proteomes:UP000198415};
RN [1] {ECO:0000313|EMBL:SNR69508.1, ECO:0000313|Proteomes:UP000198415}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43151 {ECO:0000313|EMBL:SNR69508.1,
RC ECO:0000313|Proteomes:UP000198415};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; FZNR01000004; SNR69508.1; -; Genomic_DNA.
DR Proteomes; UP000198415; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.30.1780.10; ornithine cyclodeaminase, domain 1; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR023401; ODC_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198415};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 697..774
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 873..1275
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2176..2253
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3290..3365
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1344..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2152..2174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3367..3422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1372..1386
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3367..3412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4264 AA; 439059 MW; 69A85BE7179B4D76 CRC64;
MTLIDVLVRA ATGVPAQVMV HVDGDGGERR ISYAELYADA LRVAGGLRAA GITQGDCVII
VAEDSAEFVA LFWGAVVAGA VPVPLPPEPE RVAAVQRRLG QPVPVYRTVG ELRSAPGLAE
PVPVGPDDLA LLQYSSGSTG TPKGVELTHG NLVANLEQAS RAAGTGPGDV ILTWMPYFHD
MGLIGTHLGP LYARCRQVRI SPMTFAKRPE VWLRAAHEHR ATVLTAANFA LALTVRRVRD
EVLDGLDLSA VRLVMVGAEP ISPVVWRAFR AKLGRARLEP GALQPVYGLA EATVAVAIPP
LGERARPVRL SRAALSRGVA LEVSGGATEA EPVVVGLGGA GLVDGGVGGV GAVGLVDGGV
GGVGAVGPVD VGVGGAGLVD GGLGAVGPVD ISVGGAGPVD GGAVAGGLMD VGVGGPMNVA
AGAVELMDVG FAVPGCEIRI VDDGGRPLED SLVGHIQVRG PNVTRGYHRD PSATAETLVD
GWLRTGDLGF LRAGRLCVSG RAKDVLFIHG RNFHAADLEE VAAATPGLGS GPVAVVGATD
PGSGRERVVV FISAPAVRAD PRIAELARAR VAEALGYDGV TVQVLPRGAF ARTTSGKLRR
HLLRDRLLAE NPPVDAVDAV DAVDAVDAVD AVDAVDAVDA VDAVDAVDAV DAVDAVEAAG
AAEVGAAGAA AEVGAAGDDE RLMPEMSETI APVRPPRTRA EAERVVRTAW AKVLQIPAER
IGPADRFLAI GGSSLAAMEV LADLEDAFGR TLDPATLRDC ATVPALADRL LRDCATVPDL
ADRLLRDCAT VPDLADLLLA DCATVSDLAD GATVSDLADG ATVADLADGA ASPAIADRLL
RDYATVPGFA DRLLRAGPVP TAARASASTT VGAGELAVIG MACRFPDAET PEQFWENLLA
GRDSVTRASD WDGHGAFLRD PALFDADYFG IGETEARYLD PHARIFLELA HEALERSGHA
GPRRRGRRVG VFVAVGESAY PELFDETDLD QAHALTGTLR NLTAARVAHL LDLHGPALAV
DTACSSALVA LHLARRSLNA GDCDLAVVGG VNLNLTGTAH RLLAGAQALS PTGRCRAFDA
DADGFVPGEG GAALVLTRLT DALDEGTGDR ILAVVRGTAV NNDGRSLSLM APNPLLQQRV
ISDAYRECGV DPAEVSYIEA HGTGTAVGDP IEARSLAHAL PPRPDGRPRL VGSVKTNIGH
LLNAAGLPAL VKVILSLRHG ELPPSLHHNR PSPRFDLAGA GFEVLTERRP WPGPRVAGVN
SFGFGGTNAH AILAAPPPVS APLTVAPPVV AAPDGSVSPT GSAPVTAALP KGPVPVTVAP
PSVSGPVATG PSAVVPALPS VSGPVAAAPP SVSGRVATGP SAVAAAPPSV SGPVAATPPP
VSGPGAAAPS AVPAPGAAAP SAVPAPGAAA PFPAVPALLT ISARSAEGLR AAVDDLARYL
REHPAAGEAD ICASASTARD DGPYRMAIVA EGDLAERLGS ATFSPPVGRP ARTVLVFAAP
TPDQVATASE FRTVLDQVPV EIGRILGSWH IGDEISDLVT VAFGIAVGAQ LWTFGVRPDA
VTGLGPGSLA AAVFAGALSP AEAIRSAASP DHPVSASRPV RVPLLDPVTG DHVTVLAVAG
YDTMIIAGAG AGAGAGAGAG AGAGVGAGAG AGAGVGAGAG AGAGAGVGAR AGDGAGSVGV
RGAIPEVLAA GSTTRELLVT AGELWRRGGV LDRSLLDAGT RWVELPTYPF QRRRYWVTDP
PPPVLSTPTW VETPVGSGAP VGSEAPVNSG ASVGSGAPVG SGASVGSEAP VGSGAAIGSG
TAIGNWARVD ADRTLTVMHA GREDRDALEV VPELPRSGQL LIVTEDLYAT GIGTEKPSPA
HAVWSGLAMA LADENRDLGV RVIDLTSTDP EDVQRAAVER EAANPPMPGP AQIVAWRGGR
RFTRAFVPAP ATEPLDLPPD GNYLITGGAG AAGIAIARHL ARRGHPNLLL AGRSPEPTGL
LDELRRAGAI VEYRRADVTA EPDVAALVDG HEFDVVVHAA GVVRPGSLRS KNRDELAAGM
AAKIRGTELL TRALRGSRPL VIALSSVSAV LPGLAGAVGD YVAGNAYLDA FAAAERAAGR
RFVAVDLPAL SGGGLATGHA IRAAGLPLDR LPGLLWSAAA LEVAQVLVTP SEPGAARSRR
TAPAAGTPSE DRVPHAGQGE LVALIRELLA EALEREPGTI GTDEPFLALG LDSLTAVDLV
KELENRLGRT LSTTLFFEFR TIGELAGHLG EEDLTPAAAL AEFPINSGKG RLPVADAERP
LSSGEVVTPA AGIGEFPLSP VQQAFRTNGR LYPEVPAYAH VHQTLDGPVD VDRLAAAFAE
LERRHPMLRM RFAATGQRFE AAGDGRPEWF TTVEPREPVV DLDAELRNRP FDLRVEAPVR
AVLAVPQDGP AHLILVAHHA AVDGYSLAIL GDELWTLYAG NEPAEAPENT FAEHEALRTE
PGETELAWWR DALGRYPRLA LPFDGDVGSD PAPPYAMHQV AIDADLTRQL EERARAAGVT
LFHLLLAGYV RCLARWSGQN DVPVLVARAG RTARLAGIDR MVGPFADTLP LLARVVAEES
AVVLAERLRE AWLESERHGT VSTMDLARLL AADAAGPRTA SPASFSFARF PGTDRNAFSG
TGGSVPRTVA TTAGTASAAT RLGLVCFEAH GALHFSWNYP AALFHRGTIE RFAAEHLAEI
TALASPADPE PVAPLPAVLR APAVLEAPAV PPLALVDSLP SQGALPSQGA PASLAVPASL
VGRIRAQCRR TPDGLAVLAD GKPLTYRELD EASDRLAVRL AGYGSRRIGL ITEPGPATVV
GLLGILKAGA AWVPLDAAHP RARLVSQLRR AGVTVVVSDS TVLAGAFTVV DPGDGTPGEP
PEVTTGPDDD AYVIFTSGST GRPKGVPVSH RAMVGYLDWA VETFGYHAGD RLAQTASICF
DASVRQLLGP LLVGAAVVSW DRDTVRDPDE LVHRVAADRV TVWSSVPTLW ELLLGAAEKA
AGRGGPELTA IRWVHVGGEE LSPAPVRRWF DLLGPGQRIA NLYGPTETTI NATFHVISER
PAQDVRHVPI GRPVGGAVAE VVGAEGRPCA PGETGELWIG GAGVAAGYLD DPEQTAAAFV
ERDRRRWYRS GDRAVRDADG VLWFRGRADD QVKLHGYRVE PGEAAAVLRG HPGVERAAVR
VDGKRLVAWV QPRRDVVVTG AGLRAYAEGI LPFYLVPARI EVVAELPLTL TGKIDRAALA
GGAEPSGTAA DEVLVGDGGP SFMAADGALV GDGGPSFMAA DGVLVGDGGP PRTATERVLA
RIWERHLDVP RVGRGDDFFA LGGDSIGVLE MFGALEAEIP VLPRPTVIYR HRTLAALAAE
IDAASQAASP SSSSPLSSSS SSSSSSSSSS SSSSSSSPSS SPSASASALP SHSPPSPVLP
LLSSPSALDG AAEFPLSPSQ RGFLLADAVG AESTWLAAPR LHGPIDLERF QQAVDALVAR
HPMLRTVFRG QARPPTQREL ATTAGLTVDY VAEPGLIADE LAAERRRRFD PARWPLVRLR
LLRVDEEEHV LLLHAHHLIG DGYSVALLAR ELLSVYDQSP LPPLRSSFRD YVALTNGLET
ETAPYDGAPL GRGATTATAG ITLPPEATSR LRSQAMTAGV TPVVPVLTAF HRALSATLGR
PDPVIGVAMT GRDHSLPDLA RIFGPCATAV AVRPGPPTEP AADLERMAAA MTGARGRGFV
APHGWQFLLT YLDFAALGPL RGDTLRLTWD DTDAEMAVPP GTDVLLAVRP TDDGLRLTFR
GRLPEATLAA LAARVHADLE ADLGPAVRVH ADREADLGPA VRVHADREAD LGPAVRVHTD
READLGPAVR VHADREAGLG PAVRVHADRE ADLGLAARVD AGLKVSSGQA AWMRAEPEAG
SGKPTAAGRL DAALVGYLPA PAQLAALAGD LPAAVRRMLP ELSREAIRAA IFPEGTPRLL
ETVDTPLGRS GFVCLPRFAD ELTIPGLASD AAAAADLAAT HGARTVSLAG MIPAHTGYGA
AVADLTTENV QVTTGHAVTA ASVVRTTFAA AGRNLGNRVL AVLGVGSIGS SSLSLLLAEA
DEPPAVLLLC DLPAAAARLG ALAADLRKHG YTGPIEIVTD PEAVYRADVI VAATSGGAET
IDVDRLRPGT VLVDDSFPHC FDTTRALARM RERNDVLIVG GGLLDCGPAS RTMAPGLPVS
AHPGRLPGAV ASCQLESLLH AATPGLPLVR GPVSAADVTA YGQALDLANV NAAPLHLLGV
ILHR
//
