ID A0A238YNP1_9ACTN Unreviewed; 710 AA.
AC A0A238YNP1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SNR72203.1};
GN ORFNames=SAMN06265355_10670 {ECO:0000313|EMBL:SNR72203.1};
OS Actinomadura mexicana.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=134959 {ECO:0000313|EMBL:SNR72203.1, ECO:0000313|Proteomes:UP000198420};
RN [1] {ECO:0000313|EMBL:SNR72203.1, ECO:0000313|Proteomes:UP000198420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44485 {ECO:0000313|EMBL:SNR72203.1,
RC ECO:0000313|Proteomes:UP000198420};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FZNP01000006; SNR72203.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238YNP1; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000198420; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 172..319
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 710 AA; 73750 MW; F5BB0F3F2A821890 CRC64;
MSRLLYRLGR AAALRPWRFI VVWLVLVAAM AGLSGVAGGA LHDNYTLAGT GSQQATDLLQ
ERFPALAGAD ARVVVHAESG RVDQQKLAAA AAEMRTLPHV SGVDPAQLGK GGATALITVR
YSVPVTDLGP KETLDLLRSA TRNLDAAGYQ VEFGGQVPEN VTAPGGVAEA IGIVAALVIL
LLAFGSVVAA GLPLAVALAG LGVGVSGITL VAAFTDVATT APTLATMVGL GVGIDYALFV
LTRHREGLAE GLDVPEAVGR AIATAGLSVI FAGFTVLLAL CGLVLSRIPV FMTMGFTTGI
VVAATVLSAV TLLPAVLGLA GRRVLRRRDR AAGAVITVES PRVRRWAVHV GRHPWPWLLA
AAVLMLTLAA PALGMRTWPS DASSEPTSNT VRQAYDLVAD GFGAGANGPL VVAVDLTRTD
KAALPGLRER LEGTEGVASV APPQASPRGD AAAIIVTPDY GPQDERVTGL VDRIRADVLP
PDTEVTGLTA VYVDLSRMLS DRLWPVIGVV VATSFVMLMI VFRSLLAPLK AAVMNLLSIG
AAYGVLTAVF QWGWGAELLG LPHSVPVSSF ILLLMFAVLF GVSMDYEVFL LSRVREEWLL
HGDARGSVST GLAATGRVIS SAALIMVAVF LGFAADPGLV IKQMGVGLAV AVALDATVVR
LVLVPATMSL LGRANWWLPG PLARVLPAID LHGGAKPRPA AERRPEPSRA
//
