ID A0A238ZST9_9ACTN Unreviewed; 1185 AA.
AC A0A238ZST9;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN05216252_101538 {ECO:0000313|EMBL:SNR86487.1};
OS Actinacidiphila glaucinigra.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Actinacidiphila.
OX NCBI_TaxID=235986 {ECO:0000313|EMBL:SNR86487.1, ECO:0000313|Proteomes:UP000198280};
RN [1] {ECO:0000313|EMBL:SNR86487.1, ECO:0000313|Proteomes:UP000198280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.1858 {ECO:0000313|EMBL:SNR86487.1,
RC ECO:0000313|Proteomes:UP000198280};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FZOF01000001; SNR86487.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A238ZST9; -.
DR Proteomes; UP000198280; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000198280};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1185 AA; 131039 MW; E69AEECD4925DCB2 CRC64;
MTTPFTHLHV HTQYSLLDGA ARLKDMFKAC GEMGMTHIAM TDHGNLHGAY DFFHQAKGAG
ITPIIGIEAY VAPESRRNKR KVTWGQPHQK RDDVSASGSY LHKTIWAANA TGLHNLFRLS
SDAYAEGWLT KYPRMDKETI AQWSEGLMAS TGCPSGEVQT RLRLGQFDEA VKAAAEYQDI
FGKERYFLEL MDHGIEIERR VRDGLLEIGK KLGIPPVVTN DSHYTYASEA DAHDALLCIQ
TGKNVSDPDR FRFDGTGYYL KTTDEMLGID SSDAWQEGCR NTTLLVAQQV DTDGMFQARN
LMPRFEVPEG YTEVTWFREE TMSGMRRRYP AGIPDDRMKQ VEYEMDTIIQ MGFPGYFLVV
ADFIMWAKNN GIAVGPGRGS AAGSIVAYAM GITDLDPIDH GLIFERFLNP ERISMPDVDI
DFDERRRAEV IRYVTEKYGA DKVAMIGTYG TIKAKNAIKD SARVLGYPYA VGDRLTKAMP
ADVLGKGIPL SGITDSAHPR YSEAGEIRSM YENEPDAKKV IDLARGVEGL VRQMGVHAAG
VIMSSEPIVD HAPVWVRHSD GVTITQWDYP SCESLGLLKM DFLGLRNLTI MDDAVKLVKA
NKGVDIELLA LPFDDPKTFE LLGRGDTLGV FQFDGGPMRS LLRMMKPDNF EDISAVSALY
RPGPMGMNSH INYALRKNKQ QEITPIHPAL EAPLKEVLDV TYGLIVYQEQ VQKAAQIIAG
YSLGEADILR RVMGKKKPEE LAKNFTIFQE GARKNGYSDE SIQALWDVLV PFAGYAFNKA
HSAAYGLVSY WTAYLKANYP AEYMAALLTS VRDDKDKSAI YLNECRRMGI RVLPPNVNES
DANFTAQGDD VILFGLTAVR NVGQNVVDSI IRCRKSKGKY TSFPDFLDKV EAVVCNKRTV
ESLIKAGAYD EMGHTRKGLT EHYEPMIDNV VAVKRKEAEG QFDLFGGMGD ETAGDEPGFG
LDVTFSDVEW DKTYLLAQER EMLGLYVSDH PLFGIEHVLN DKADASVSAL AGDYSDGSIV
TIGGIISGLQ RKMTKQGNAW AIATVEDLGG SIDCMFFPAT YQLISTQLVE DAVVFVKGRL
DKREDIPRLV AMELMVPDLT DAGTNAPVTI SIPTVKVTPP LVARLGEVLA SHKGSTEVRV
RLQGARKTTV LRLDRHRVTA DPALFGDLKA LLGPSCLATA QQQAG
//