ID A0A239BGQ3_9ACTN Unreviewed; 455 AA.
AC A0A239BGQ3;
DT 25-OCT-2017, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=SAMN05216276_1003170 {ECO:0000313|EMBL:SNS06538.1};
OS Streptosporangium subroseum.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Streptosporangium.
OX NCBI_TaxID=106412 {ECO:0000313|EMBL:SNS06538.1, ECO:0000313|Proteomes:UP000198282};
RN [1] {ECO:0000313|EMBL:SNS06538.1, ECO:0000313|Proteomes:UP000198282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.2132 {ECO:0000313|EMBL:SNS06538.1,
RC ECO:0000313|Proteomes:UP000198282};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
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DR EMBL; FZOD01000003; SNS06538.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A239BGQ3; -.
DR OrthoDB; 108135at2; -.
DR Proteomes; UP000198282; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.10.450.280; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR040846; ORF_12_N.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR Pfam; PF18042; ORF_12_N; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Reference proteome {ECO:0000313|Proteomes:UP000198282};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..455
FT /note="beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038795533"
FT DOMAIN 46..135
FT /note="ORF 12 gene product N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18042"
FT DOMAIN 186..287
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 455 AA; 49164 MW; 90F0B26DCA13EC6D CRC64;
MRLPFRSTRF LTLAVVTAAV PFTSLAGGGQ PATASTAQVV TVAPEIPDSP AGRQLRWFLD
APSRAPLTES ELGEHVNAAY LQALTVDGFN AFLKNATGFQ LEELTTVTPT ALVGTGAIGS
QKFVLQLRVD AAGKINLIGA TPPAPPIPAS PTSWKQLDTR LRKAAPQVGF LAAEIDSRGR
CEVVHAVNPD RAQPLGSIFK LYVMGAVAEK IRDDRLSWNT KLTIRPEWRS TGEGGLAERP
DNSTVTVREA AKLMISISDN TATDLLIHTV GRGAVESTVR RWSGHAKQNV PFLTTRELFL
LKGVNYPGQA NAYLALRPAK KAAYLKNTVA KQALTDIRPW DRPREIDRLE WFGSPRDVCR
AYAGLATLNS KPLHEAMSAD DLGLKLDPRK WPVVWAKGGS ELGVLDLSFR ARSAKEKTYV
VTALTNNPQS AIDERTAVGE LISLSRGAFT LATSG
//
